Linked Life Data

15763978

Source:http://linkedlifedata.com/resource/pubmed/id/15763978

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2005-3-14
pubmed:abstractText
We tested a set of commercially available probes to determine the feasibility and accuracy of FISH in the detection of abnormalities in 13 patients with Chronic Lymphocytic Leukemia (CLL) with a particular aggressive clinical disease. We utilized three different probes for the 13q12-14 region, one for the centromeric region of chromosome 12, one for the P53 gene at 17p13.1 and one for 3'-5' IGH at 14q32, covering the entire region of IGH, thus potentially allowing to detect more rearrangements. Conventional cytogenetic study showed a normal karyotype in 8/13 patients. FISH was able to detect chromosomal abnormalities in 10/13 pts (85%): +12 in 4 pts (38%); del 13q in 4 (38%); del 17p in 3 (35%); del of 5'-IGH in 1 (15%). In conclusion FISH confirmed its ability to improve the detection of cytogenetic abnormalities especially in patients with an aggressive disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1024-5332
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
383-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Molecular cytogenetic analysis of B-CLL patients with aggressive disease.
pubmed:affiliation
Department of Medicine and Immunological Sciences, Division of Hematology and Transplants, University of Siena, Siena, Italy. gozzetti.unisi.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't