Source:http://linkedlifedata.com/resource/pubmed/id/15762668
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2005-3-14
|
pubmed:abstractText |
Polysaccharide-protein conjugations have generated increasing interests for biomedical applications in recent years. A naturally occurring cross-linking reagent, genipin, which has been used in herbal medicine, was employed to cross-link chitosan and gelatin for the preparation of a novel chitosan-gelatin conjugate. The primary amine groups on chitosan and gelatin were covalently linked with genipin, leading to the formation of a chitosan-gelatin conjugate with nitrogen-containing heterocycle units, the pyrindine-like derivatives. The FT-IR and UV-vis studies revealed that chitosan could react with genipin via a nucleophilic ring-opening reaction to construct more sufficient and extensive cross-link networks, as compared with its gelatin counterpart. The UV-vis absorption properties of the chitosan-gelatin conjugates were strongly related to the chitosan-to-gelatin weight ratio in the compositions. It is worth noting that the conjugation process endows the special emission properties of the chitosan-gelatin conjugates, which depends on the cross-linking reaction and the formation of hydrogen bonding involved chitosan-gelatin complex. Fluorescence quenching or enhancement was observed from the chitosan-gelatin conjugates upon coordinated with a wide variety of heavy metal ions (Ag+, Cu2+, Fe2+, and Co2+). This study also examined the possibility of covalent coupling the capture chelator (chitosan) with bioactive protein (e.g., albumin, alpha-globulin, and fibrinogen) to create fluorescence emission. These findings may provide a novel way to deliver therapeutic radionuclides for immuno-targeting purposes in the future.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Chitosan,
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Gelatin,
http://linkedlifedata.com/resource/pubmed/chemical/Iridoid Glycosides,
http://linkedlifedata.com/resource/pubmed/chemical/Iridoids,
http://linkedlifedata.com/resource/pubmed/chemical/Metals,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrans,
http://linkedlifedata.com/resource/pubmed/chemical/genipin
|
pubmed:status |
MEDLINE
|
pubmed:issn |
1525-7797
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
6
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
975-87
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:15762668-Adjuvants, Immunologic,
pubmed-meshheading:15762668-Chitosan,
pubmed-meshheading:15762668-Cross-Linking Reagents,
pubmed-meshheading:15762668-Drug Delivery Systems,
pubmed-meshheading:15762668-Fluorescence,
pubmed-meshheading:15762668-Gelatin,
pubmed-meshheading:15762668-Iridoid Glycosides,
pubmed-meshheading:15762668-Iridoids,
pubmed-meshheading:15762668-Metals,
pubmed-meshheading:15762668-Pyrans,
pubmed-meshheading:15762668-Spectrum Analysis
|
pubmed:articleTitle |
Synthesis and characterization of a novel chitosan-gelatin bioconjugate with fluorescence emission.
|
pubmed:affiliation |
Division of Applied Chemistry, Department of Applied Science, Chinese Naval Academy, 669 Jiun Shiaw Road, Kaohsiung, Taiwan 813, ROC. flmi@cna.edu.tw
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|