|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2005-3-14
|
|
pubmed:abstractText |
The di-sulfonated di-phthalimidomethyl phthalocyanine zinc (ZnPcS2P2) was an amphiphilic photosensitizer for photodynamic therapy of cancer. According to fluorescence analytical method, extracting efficiencies of 2.0% SDS (Wt%), 1.5% Triton X-100 (phi) and DMF for ZnPcS2P2 in K562 cells were compared. The results showed that 1.5% Triton X-100 was the most efficient reagent for the first time extracting. Using 1.5% Triton X-100 as extracting reagent, the kinetic curves of cellular uptake of ZnPcS2P2 as well as LDL-ZnPcS2P2 complex by K562 cells were determined. Compared with ZnPcS2P2, the maximum cellular uptake of LDL-ZnPcS2P2 by K562 was doubled, which indicated that LDL was an effective targeting delivery vehicle for ZnPcS2P2.
|
|
pubmed:language |
chi
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1000-0593
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1415-8
|
|
pubmed:meshHeading |
pubmed-meshheading:15762492-DNA,
pubmed-meshheading:15762492-Genes, abl,
pubmed-meshheading:15762492-Humans,
pubmed-meshheading:15762492-Indoles,
pubmed-meshheading:15762492-K562 Cells,
pubmed-meshheading:15762492-Octoxynol,
pubmed-meshheading:15762492-Organometallic Compounds,
pubmed-meshheading:15762492-Photochemotherapy,
pubmed-meshheading:15762492-Photosensitizing Agents,
pubmed-meshheading:15762492-Tumor Cells, Cultured
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
[Determination and pharmacokinetics of photosensitizer ZnPcS2P2 uptaken by K562 cells].
|
|
pubmed:affiliation |
Department of Chemistry, Institute of Research on Functional Materials, Fuzhou University, Fuzhou 350002, China.
|
|
pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|
