Source:http://linkedlifedata.com/resource/pubmed/id/15761491
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2005-6-21
|
| pubmed:abstractText |
Rhabdoid cells are encountered in specific entities, such as malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor, as well as in composite rhabdoid tumors derived secondarily from other tumor types. Although rhabdoid tumors are uniformly aggressive, distinction of the entity from the phenotype remains important for its therapeutic implications. The majority of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors affect infants and young children, harbor chromosome 22q deletions, and inactivate the INI1/hSNF5/BAF47 tumor suppressor gene on 22q11.2. In contrast, most composite rhabdoid tumors are diagnosed in adults, with FISH detectable 22q losses the exception rather than the rule. However, this assay remains limited since 22q dosages are maintained in 20-30% of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors. Furthermore, chromosome 22 losses are common in some parent tumor types, particularly meningiomas. The recently developed INI1 antibody shows loss of nuclear expression in malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors, though its status in composite rhabdoid tumors is largely unknown. Therefore, we utilized immunohistochemistry and FISH to study INI1 expression and 22q dosages, respectively, in 40 composite rhabdoid tumors, including 16 meningiomas, 15 carcinomas, three melanomas, two sarcomas, two glioblastomas, and 1 neuroblastoma. Approximately 70% of rhabdoid meningiomas had a 22q deletion, but this was rare in other tumor types. Except for one retroperitoneal leiomyosarcoma, nuclear INI1 expression was retained in all composite rhabdoid tumors, including meningiomas with 22q deletion. Therefore, we conclude that INI1 immunohistochemistry is a relatively simple, sensitive, and specific technique for distinguishing malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor from composite rhabdoid tumor.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0893-3952
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
951-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:15761491-Adult,
pubmed-meshheading:15761491-Aged,
pubmed-meshheading:15761491-Child,
pubmed-meshheading:15761491-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:15761491-Chromosome Deletion,
pubmed-meshheading:15761491-Chromosomes, Human, Pair 22,
pubmed-meshheading:15761491-DNA-Binding Proteins,
pubmed-meshheading:15761491-Female,
pubmed-meshheading:15761491-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15761491-Humans,
pubmed-meshheading:15761491-Immunohistochemistry,
pubmed-meshheading:15761491-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15761491-Infant,
pubmed-meshheading:15761491-Male,
pubmed-meshheading:15761491-Meningeal Neoplasms,
pubmed-meshheading:15761491-Meningioma,
pubmed-meshheading:15761491-Middle Aged,
pubmed-meshheading:15761491-Rhabdoid Tumor,
pubmed-meshheading:15761491-Transcription Factors
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas.
|
| pubmed:affiliation |
Department of Pathology, Washington University School of Medicine, St Louis, MO 63001-1093, USA. aperry@wustl.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
|