Source:http://linkedlifedata.com/resource/pubmed/id/15760401
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 1
|
| pubmed:dateCreated |
2005-3-11
|
| pubmed:abstractText |
Significant mortality is associated with post-transplant lymphoproliferative disorder (PTLD) in kidney transplant recipients (KTX). Univariate/multivariate risk factor survival analysis of US PTLD KTX reported to Israel Penn International Transplant Tumor Registry from November 1968 to January 2000 was performed. PTLD presented 18 (median) (range 1-310) months in 402 KTX. Death rates were greater for those diagnosed within 6 months (64%) versus beyond 6 months (54%, p = 0.04). No differences in death risk for gender, race, immunosuppression, EBV, B or T cell positivity were identified. Death risk increased for multiple versus single sites (73% vs. 53%, hazards ratio (HR) 1.4). A 1-year increase in age increased HR for death by 2%. Surgery was associated with increased survival (55% vs. 0% without surgery) (p < 0.0001). Patients with allograft involvement, treated with transplant nephrectomy alone (n = 20), had 80% survival versus 53% without allograft removal (n = 15) (p < 0.001). Overall survival was 69% for allograft involvement alone versus 36% for other organ involvement plus allograft (n = 19 alive) (p < 0.0001). Death risk was greater for multiple site PTLD and increasing age, and risks were additive. Univariate analysis identified increased death risk for those not receiving surgery, particularly allograft involvement alone.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
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| pubmed:issn |
1600-6135
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
775-80
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| pubmed:dateRevised |
2007-2-14
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| pubmed:meshHeading |
pubmed-meshheading:15760401-Graft Rejection,
pubmed-meshheading:15760401-Immunosuppression,
pubmed-meshheading:15760401-Kidney Transplantation,
pubmed-meshheading:15760401-Lymphoproliferative Disorders,
pubmed-meshheading:15760401-Registries,
pubmed-meshheading:15760401-Survival,
pubmed-meshheading:15760401-Survival Analysis
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Analysis of factors that influence survival with post-transplant lymphoproliferative disorder in renal transplant recipients: the Israel Penn International Transplant Tumor Registry experience.
|
| pubmed:affiliation |
Israel Penn International Transplant Tumor Registry, Division of Transplantation, University of Cincinnati, Cincinnati, OH, USA. jennifer.trofe@uphs.upenn.edu
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| pubmed:publicationType |
Journal Article
|