Linked Life Data

1575887

Source:http://linkedlifedata.com/resource/pubmed/id/1575887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-6-9
pubmed:abstractText
The anticancer agents doxorubicin and daunorubicin were covalently linked to the water-soluble anionic polysaccharides hyaluronic acid and carboxy-methylcellulose. The drug-polymer conjugates are in principle prevented from entering cells, can efficiently bind to cell surfaces and allow precise dose-response determinations. In addition, they are not able to bind DNA because of their negative charge. Cell growth and DNA synthesis inhibition studies indicated decreased cell toxicity for the polymer conjugates. The mol. wt of the carrier was shown to affect the biological activity of the anthracycline to a moderate extent. Partial drug incorporation into cells was observed as a function of time, probably due to endocytosis phenomena followed by biochemical cleavage of the conjugate. The conclusion was drawn that membrane binding appears to contribute to total toxicity only to a minor extent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0266-9536
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-51
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Water-soluble polysaccharide-anthracycline conjugates: biological activity.
pubmed:affiliation
Department of Pharmaceutical Sciences, Centro Studi sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi, Padova, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't