Source:http://linkedlifedata.com/resource/pubmed/id/15758247
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2005-3-10
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pubmed:abstractText |
Adiponectin appears to be an important modulator for metabolic and vascular diseases. A case-controlled study was designed to measure plasma adiponectin levels and investigate the effects of rosiglitazone on adiponectin levels in type 2 diabetic patients with proteinuria. Sixty-four patients (mean age, 46.1+/-4.6 yr; 30 male, 34 female) and 26 healthy volunteers (mean age, 45.3+/-4.8 yr; 14 male, 12 female) were included. Patients with proteinuria were treated with 4-mg/d rosiglitazone (n=21, 10 males, 11 females) for 4 wk. Adiponectin levels in patients were significantly lower than those of controls (p<0.001). There were significant negative correlations between adiponectin concentrations and insulin levels as well as homeostasis model assessment (HOMA) index in patient's group (r=-<FONT "Optima">0.538, p<0.001; r=-<FONT "Optima">0.393, p=0.001, respectively). There was also a significant negative correlation between plasma adiponectin concentrations and the degree of proteinuria (r=-<FONT "Optima">0.526, p=0.002). Plasma adiponectin levels in patients with proteinuria (n=31; 3.91+/-2.57 microg/mL) were significantly lower than those without proteinuria (n=33; 10.15+/-1.97 microg/mL) (p<0.001). After the treatment period, adiponectin levels significantly increased (p<0.001) and proteinuria, plasma insulin, and HOMA indexes significantly decreased in treatment group (p<0.001, p<0.001, p<0.001, respectively). The results suggest that adiponectin is inversely correlated with proteinuria and treatment with peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist rosiglitazone both corrects proteinuria and increases the low adiponectin levels in diabetic patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/rosiglitazone
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1355-008X
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pubmed:author |
pubmed-author:AcikelCengizhanC,
pubmed-author:BingolNecatiN,
pubmed-author:CaglarKayserK,
pubmed-author:EyiletenTayfunT,
pubmed-author:GokDeniz EnginDE,
pubmed-author:KilicSelimS,
pubmed-author:OguzYusufY,
pubmed-author:SonmezAlperA,
pubmed-author:VuralAbdulgaffarA,
pubmed-author:YenicesuMüjdatM,
pubmed-author:YilmazMahmut IlkerMI
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-14
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15758247-Adipocytes,
pubmed-meshheading:15758247-Adiponectin,
pubmed-meshheading:15758247-Adult,
pubmed-meshheading:15758247-Case-Control Studies,
pubmed-meshheading:15758247-Diabetes Mellitus, Type 2,
pubmed-meshheading:15758247-Female,
pubmed-meshheading:15758247-Homeostasis,
pubmed-meshheading:15758247-Humans,
pubmed-meshheading:15758247-Hypoglycemic Agents,
pubmed-meshheading:15758247-Insulin,
pubmed-meshheading:15758247-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15758247-Male,
pubmed-meshheading:15758247-Matched-Pair Analysis,
pubmed-meshheading:15758247-Middle Aged,
pubmed-meshheading:15758247-Models, Biological,
pubmed-meshheading:15758247-PPAR gamma,
pubmed-meshheading:15758247-Proteinuria,
pubmed-meshheading:15758247-Reference Values,
pubmed-meshheading:15758247-Thiazolidinediones
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pubmed:year |
2004
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pubmed:articleTitle |
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist increases plasma adiponectin levels in type 2 diabetic patients with proteinuria.
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pubmed:affiliation |
Nephrology Department of Gülhane School of Medicine, 06018 Etlik-Ankara, Turkey. mahmutiyilmaz@yahoo.com
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
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