Linked Life Data

15756599

Source:http://linkedlifedata.com/resource/pubmed/id/15756599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-6-3
pubmed:abstractText
Administration of radiolabelled deprenyl to rats resulted in the urinary elimination of a (14)C-labelled N(epsilon)-monomethyl-lysine. An increased level of N(epsilon)-monomethyl-lysine was found following an oral dose of another drug, also containing an N-methyl group. The urine sample was treated with 9-fluorenylmethoxycarbonyl chloride and then subjected to high-performance liquid chromatography (HPLC); the radioactive fraction was identified as N(epsilon)-monomethyl-lysine by using HPLC-MS in electrospray mode. Identification of N(epsilon)-monomethyl-lysine in the radioactive fraction gives experimental proof of transmethylation from a well-known drug to an endogenous compound.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1618-2642
pubmed:author
pubmed:issnType
Print
pubmed:volume
382
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
760-4
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Detection of N-monomethyl-lysine generated by metabolic transmethylation.
pubmed:affiliation
Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary. Huba@kalasz.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't