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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-3-9
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|
pubmed:abstractText |
Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. Continuous inhibition of EGFR signaling is thought necessary for optimal inhibition of tumor cell proliferation. We hypothesized that continuous gefitinib may antagonize the effects of cytotoxics that inhibit tumor cells in other phases of the cell cycle. Furthermore, we hypothesized that intermittent dosing would allow for dose escalation and greater inhibition of EGFR-dependent antiapoptotic pathways.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Mar
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|
pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
11
|
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1983-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15756024-Animals,
pubmed-meshheading:15756024-Antineoplastic Agents,
pubmed-meshheading:15756024-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:15756024-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15756024-Breast Neoplasms,
pubmed-meshheading:15756024-Drug Administration Schedule,
pubmed-meshheading:15756024-Drug Interactions,
pubmed-meshheading:15756024-Female,
pubmed-meshheading:15756024-Mice,
pubmed-meshheading:15756024-Mice, Nude,
pubmed-meshheading:15756024-Paclitaxel,
pubmed-meshheading:15756024-Quinazolines,
pubmed-meshheading:15756024-Transplantation, Heterologous,
pubmed-meshheading:15756024-Tumor Cells, Cultured
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
Pulsatile administration of the epidermal growth factor receptor inhibitor gefitinib is significantly more effective than continuous dosing for sensitizing tumors to paclitaxel.
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pubmed:affiliation |
Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. solitd@mskcc.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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