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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-8
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pubmed:abstractText |
Changes in cardiac function due to sepsis have been widely reported. However, the underlying mechanisms remain poorly understood. In the mammalian heart, myocyte function and intracellular calcium homeostasis are closely coupled. In this study we tested the hypothesis that alterations in cardiac calcium homeostasis due to sepsis underlie the observed myocyte dysfunction.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0090-3493
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
598-604
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15753753-Animals,
pubmed-meshheading:15753753-Calcium,
pubmed-meshheading:15753753-Calcium Signaling,
pubmed-meshheading:15753753-Cytosol,
pubmed-meshheading:15753753-Homeostasis,
pubmed-meshheading:15753753-Male,
pubmed-meshheading:15753753-Myocardial Contraction,
pubmed-meshheading:15753753-Myocytes, Cardiac,
pubmed-meshheading:15753753-Prospective Studies,
pubmed-meshheading:15753753-Random Allocation,
pubmed-meshheading:15753753-Rats,
pubmed-meshheading:15753753-Rats, Sprague-Dawley,
pubmed-meshheading:15753753-Sarcoplasmic Reticulum,
pubmed-meshheading:15753753-Sepsis
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pubmed:year |
2005
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pubmed:articleTitle |
Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis.
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pubmed:affiliation |
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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