Source:http://linkedlifedata.com/resource/pubmed/id/15753665
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2005-3-8
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| pubmed:abstractText |
In vitro gamma-radiation-induced chromatid breaks per cell (b/c) in lymphocytes may be associated with risk of papillary thyroid cancer (PTC). This pilot case-control study involved 106 patients with thyroid disease (57 with PTC and 49 with benign thyroid disease) and 105 cancer-free matched controls. Multivariate logistic regression analyses identified that an elevated gamma-radiation-induced b/c value was a risk factor for PTC (adjusted odds ratio = 4.54; 95% CI, 2.07-9.95), and a dose-response relationship was evident when the b/c values were categorized into tertiles. High levels of chromatid breaks induced by gamma-radiation may constitute an independent risk factor for PTC, but further study is needed.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1050-7256
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
94-9
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15753665-Adolescent,
pubmed-meshheading:15753665-Adult,
pubmed-meshheading:15753665-Aged,
pubmed-meshheading:15753665-Aged, 80 and over,
pubmed-meshheading:15753665-Carcinoma, Papillary,
pubmed-meshheading:15753665-Case-Control Studies,
pubmed-meshheading:15753665-Female,
pubmed-meshheading:15753665-Gamma Rays,
pubmed-meshheading:15753665-Humans,
pubmed-meshheading:15753665-Logistic Models,
pubmed-meshheading:15753665-Male,
pubmed-meshheading:15753665-Middle Aged,
pubmed-meshheading:15753665-Multivariate Analysis,
pubmed-meshheading:15753665-Neoplasms, Radiation-Induced,
pubmed-meshheading:15753665-Pilot Projects,
pubmed-meshheading:15753665-Risk Factors,
pubmed-meshheading:15753665-Thyroid Diseases,
pubmed-meshheading:15753665-Thyroid Neoplasms
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer.
|
| pubmed:affiliation |
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4009, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|