| pubmed-article:15753318 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15753318 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15753318 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15753318 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15753318 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:15753318 | lifeskim:mentions | umls-concept:C1515568 | lld:lifeskim |
| pubmed-article:15753318 | lifeskim:mentions | umls-concept:C2698594 | lld:lifeskim |
| pubmed-article:15753318 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15753318 | pubmed:dateCreated | 2005-3-16 | lld:pubmed |
| pubmed-article:15753318 | pubmed:abstractText | Antigen-specificity is a hallmark of adaptive T cell-mediated immune responses. CD4+CD25+FOXP3+ regulatory T cells (T(R)) also require activation through the T cell receptor for function. Although these cells require antigen-specific activation, they are generally able to suppress bystander T cell responses once activated. This raises the possibility that antigen-specific T(R) may be useful therapeutically by localizing generalized suppressive activity to tissues expressing select target antigens. Here, we demonstrate that T(R) specific for particular peptide-MHC complexes can be generated from human CD4+CD25- T cells in vitro and isolated by using HLA class II tetramers. Influenza hemagglutinin epitopes were used to generate hemagglutinin-specific T(R), which required cognate antigen for activation but which subsequently suppressed noncognate bystander T cell responses as well. These findings have implications for the generation of therapeutic regulatory T cells in disease, and also suggest an important mechanism by which T cells may be regulated at the site of inflammation. | lld:pubmed |
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| pubmed-article:15753318 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15753318 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15753318 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15753318 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15753318 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15753318 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15753318 | pubmed:author | pubmed-author:ZieglerSteven... | lld:pubmed |
| pubmed-article:15753318 | pubmed:author | pubmed-author:BucknerJane... | lld:pubmed |
| pubmed-article:15753318 | pubmed:author | pubmed-author:NepomGerald... | lld:pubmed |
| pubmed-article:15753318 | pubmed:author | pubmed-author:CarsonBryan... | lld:pubmed |
| pubmed-article:15753318 | pubmed:author | pubmed-author:WalkerMindi... | lld:pubmed |
| pubmed-article:15753318 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15753318 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15753318 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:15753318 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15753318 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15753318 | pubmed:pagination | 4103-8 | lld:pubmed |
| pubmed-article:15753318 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15753318 | pubmed:meshHeading | pubmed-meshheading:15753318... | lld:pubmed |
| pubmed-article:15753318 | pubmed:meshHeading | pubmed-meshheading:15753318... | lld:pubmed |
| pubmed-article:15753318 | pubmed:meshHeading | pubmed-meshheading:15753318... | lld:pubmed |
| pubmed-article:15753318 | pubmed:meshHeading | pubmed-meshheading:15753318... | lld:pubmed |
| pubmed-article:15753318 | pubmed:meshHeading | pubmed-meshheading:15753318... | lld:pubmed |
| pubmed-article:15753318 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15753318 | pubmed:articleTitle | De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells. | lld:pubmed |
| pubmed-article:15753318 | pubmed:affiliation | Diabetes Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA. | lld:pubmed |
| pubmed-article:15753318 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15753318 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15753318 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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