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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-3-16
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pubmed:abstractText |
Antigen-specificity is a hallmark of adaptive T cell-mediated immune responses. CD4+CD25+FOXP3+ regulatory T cells (T(R)) also require activation through the T cell receptor for function. Although these cells require antigen-specific activation, they are generally able to suppress bystander T cell responses once activated. This raises the possibility that antigen-specific T(R) may be useful therapeutically by localizing generalized suppressive activity to tissues expressing select target antigens. Here, we demonstrate that T(R) specific for particular peptide-MHC complexes can be generated from human CD4+CD25- T cells in vitro and isolated by using HLA class II tetramers. Influenza hemagglutinin epitopes were used to generate hemagglutinin-specific T(R), which required cognate antigen for activation but which subsequently suppressed noncognate bystander T cell responses as well. These findings have implications for the generation of therapeutic regulatory T cells in disease, and also suggest an important mechanism by which T cells may be regulated at the site of inflammation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-10049952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-10606632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-10784608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11137993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11359821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11369708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11390435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11390437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11418648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11466340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11483607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11675346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11722621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11781238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-11869680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12115645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12370347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12391178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12429857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12438424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12466842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12515818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12522256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12612578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12612581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12658273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12734345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-12775574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-14597769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-14599847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-14676299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-14722622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-14738769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-14764692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-14976053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-15024101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-15148338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-15184499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-15184500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-15336780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-15466453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-15585848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-7520605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-7636184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753318-8691133
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4103-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2005
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pubmed:articleTitle |
De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells.
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pubmed:affiliation |
Diabetes Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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