Linked Life Data

15753253

Source:http://linkedlifedata.com/resource/pubmed/id/15753253

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15753253rdf:typepubmed:Citationlld:pubmed
pubmed-article:15753253lifeskim:mentionsumls-concept:C0038170lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0040549lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0441472lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0600688lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C2244989lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0205369lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0021469lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C1522538lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0332206lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0758434lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0758436lld:lifeskim
pubmed-article:15753253lifeskim:mentionsumls-concept:C0051920lld:lifeskim
pubmed-article:15753253pubmed:issue3lld:pubmed
pubmed-article:15753253pubmed:dateCreated2005-3-8lld:pubmed
pubmed-article:15753253pubmed:abstractTextToxic shock syndrome toxin 1 (TSST-1), produced by Staphylococcus aureus (including methicillin-resistant S. aureus), is a superantigenic toxin responsible for toxic shock syndrome as well as neonatal TSS-like exanthematous disease. TSST-1 exhibits its deleterious effects by leading to the abnormal proliferation of, e.g., Vbeta2+ T cells and overproduction of proinflammatory cytokines. In the present study we examined the inhibitory effect of a Chinese herbal extract, anisodamine, on TSST-1 using human peripheral blood mononuclear cells (PBMCs). Anisodamine inhibited the production of proinflammatory cytokines better than interleukin-10 (an anti-inflammatory cytokine). The inhibitory effect of anisodamine was greater than that of any tropane alkaloid examined. Anisodamine acted directly on both monocytes and T cells in human PBMCs, and the effect was confirmed at the transcriptional level. Inhibition of NF-kappaB activation was also demonstrated. In contrast, no significant inhibition of Vbeta2+ T-cell proliferation was observed. In mice injected with TSST-1, anisodamine treatment significantly decreased serum proinflammatory cytokine levels and prevented TSST-1-induced death. These results suggest that anisodamine specifically acts against the production of cytokines (inflammatory cytokines in particular) and not against Vbeta2+ T-cell proliferation and that anisodamine may have a beneficial effect on TSST-1-associated disease.lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:languageenglld:pubmed
pubmed-article:15753253pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:citationSubsetIMlld:pubmed
pubmed-article:15753253pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15753253pubmed:statusMEDLINElld:pubmed
pubmed-article:15753253pubmed:monthMarlld:pubmed
pubmed-article:15753253pubmed:issn1071-412Xlld:pubmed
pubmed-article:15753253pubmed:authorpubmed-author:YamamotoTatsu...lld:pubmed
pubmed-article:15753253pubmed:authorpubmed-author:ImanishiKen'i...lld:pubmed
pubmed-article:15753253pubmed:authorpubmed-author:UchiyamaTakeh...lld:pubmed
pubmed-article:15753253pubmed:authorpubmed-author:TaneikeIkueIlld:pubmed
pubmed-article:15753253pubmed:authorpubmed-author:NakagawaSaori...lld:pubmed
pubmed-article:15753253pubmed:authorpubmed-author:KushiyaKojiKlld:pubmed
pubmed-article:15753253pubmed:issnTypePrintlld:pubmed
pubmed-article:15753253pubmed:volume12lld:pubmed
pubmed-article:15753253pubmed:ownerNLMlld:pubmed
pubmed-article:15753253pubmed:authorsCompleteYlld:pubmed
pubmed-article:15753253pubmed:pagination399-408lld:pubmed
pubmed-article:15753253pubmed:dateRevised2010-9-21lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:meshHeadingpubmed-meshheading:15753253...lld:pubmed
pubmed-article:15753253pubmed:year2005lld:pubmed
pubmed-article:15753253pubmed:articleTitleSpecific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin 1 (TSST-1), leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.lld:pubmed
pubmed-article:15753253pubmed:affiliationDivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 Ichibanchou, Asahimachidori, Niigata 951-8510, Japan.lld:pubmed
pubmed-article:15753253pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15753253pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed