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rdf:type |
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lifeskim:mentions |
umls-concept:C0021469,
umls-concept:C0026809,
umls-concept:C0038170,
umls-concept:C0040549,
umls-concept:C0051920,
umls-concept:C0205369,
umls-concept:C0332206,
umls-concept:C0441472,
umls-concept:C0600688,
umls-concept:C0758434,
umls-concept:C0758436,
umls-concept:C1522538,
umls-concept:C2244989
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-8
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pubmed:abstractText |
Toxic shock syndrome toxin 1 (TSST-1), produced by Staphylococcus aureus (including methicillin-resistant S. aureus), is a superantigenic toxin responsible for toxic shock syndrome as well as neonatal TSS-like exanthematous disease. TSST-1 exhibits its deleterious effects by leading to the abnormal proliferation of, e.g., Vbeta2+ T cells and overproduction of proinflammatory cytokines. In the present study we examined the inhibitory effect of a Chinese herbal extract, anisodamine, on TSST-1 using human peripheral blood mononuclear cells (PBMCs). Anisodamine inhibited the production of proinflammatory cytokines better than interleukin-10 (an anti-inflammatory cytokine). The inhibitory effect of anisodamine was greater than that of any tropane alkaloid examined. Anisodamine acted directly on both monocytes and T cells in human PBMCs, and the effect was confirmed at the transcriptional level. Inhibition of NF-kappaB activation was also demonstrated. In contrast, no significant inhibition of Vbeta2+ T-cell proliferation was observed. In mice injected with TSST-1, anisodamine treatment significantly decreased serum proinflammatory cytokine levels and prevented TSST-1-induced death. These results suggest that anisodamine specifically acts against the production of cytokines (inflammatory cytokines in particular) and not against Vbeta2+ T-cell proliferation and that anisodamine may have a beneficial effect on TSST-1-associated disease.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-10391869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-10437167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-10464169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-10580640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-10931129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-11104794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-11173990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-11174465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-11238116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-11419178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-11597034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-11730841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-11957132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-12472182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-15122526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-15388243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-1730929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-2524876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-293694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-3780890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-4375846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-4633886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-6085785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-6242467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-6302797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-6970727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-7057538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-7207228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-7561220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-8325325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-8515079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-9301354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-9551963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-9620715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15753253-9700510
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1071-412X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
399-408
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:15753253-Animals,
pubmed-meshheading:15753253-Bacterial Toxins,
pubmed-meshheading:15753253-Cell Proliferation,
pubmed-meshheading:15753253-Cytokines,
pubmed-meshheading:15753253-Down-Regulation,
pubmed-meshheading:15753253-Drugs, Chinese Herbal,
pubmed-meshheading:15753253-Enterotoxins,
pubmed-meshheading:15753253-Humans,
pubmed-meshheading:15753253-Leukocytes, Mononuclear,
pubmed-meshheading:15753253-Mice,
pubmed-meshheading:15753253-Monocytes,
pubmed-meshheading:15753253-Solanaceous Alkaloids,
pubmed-meshheading:15753253-Superantigens,
pubmed-meshheading:15753253-T-Lymphocytes,
pubmed-meshheading:15753253-Transcription, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin 1 (TSST-1), leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.
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pubmed:affiliation |
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 Ichibanchou, Asahimachidori, Niigata 951-8510, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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