Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-6-4
pubmed:abstractText
In a cross-sectional house-to-house study in a leishmaniasis-endemic area in Kenya, the cellular and humoral immune response to Leishmania lipophosphoglycan (LPG) was determined. Clinical data, peripheral blood mononuclear cells, and plasma were obtained from 50 individuals over the age of eight years. Lymphoproliferation and interferon-gamma (IFN-gamma) production by these cells were examined. It was shown that cells from all six individuals in the population with a history of kala-azar responded to LPG in the lymphocyte proliferation assay, and four of these six responded in the IFN-gamma assay. In contrast, cells from 12 of 44 individuals from the study area with no history of kala-azar and none of the five Danish control samples responded to LPG. Antibodies against LPG were detected by enzyme-linked immunosorbent assay in 45 of 50 plasma samples. Our findings clearly show that mononuclear cells from kala-azar patients cured of infection were able to respond to the LPG preparation. The finding of a specific cellular immune response to LPG in 12 of 44 individuals with no history of kala-azar is consistent with previous epidemiologic studies, in which it has been shown that a proportion of L. donovani infections run a subclinical course. The high frequency of individuals with antibodies against LPG might indicate that a majority of the population had been exposed to the parasite.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9637
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
480-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:1575296-Adolescent, pubmed-meshheading:1575296-Adult, pubmed-meshheading:1575296-Animals, pubmed-meshheading:1575296-Antibodies, Protozoan, pubmed-meshheading:1575296-Antigens, Protozoan, pubmed-meshheading:1575296-Child, pubmed-meshheading:1575296-Cross-Sectional Studies, pubmed-meshheading:1575296-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:1575296-Female, pubmed-meshheading:1575296-Glycosphingolipids, pubmed-meshheading:1575296-Humans, pubmed-meshheading:1575296-Immunity, Cellular, pubmed-meshheading:1575296-Interferon-gamma, pubmed-meshheading:1575296-Kenya, pubmed-meshheading:1575296-Leishmania tropica, pubmed-meshheading:1575296-Leishmaniasis, Cutaneous, pubmed-meshheading:1575296-Leishmaniasis, Visceral, pubmed-meshheading:1575296-Lymphocyte Activation, pubmed-meshheading:1575296-Male, pubmed-meshheading:1575296-Tuberculin
pubmed:year
1992
pubmed:articleTitle
Cellular and humoral immune responses in a population from the Baringo District, Kenya to Leishmania promastigote lipophosphoglycan.
pubmed:affiliation
Department of Infectious Diseases, State University Hospital, Copenhagen, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't