|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0019704,
umls-concept:C0021311,
umls-concept:C0022688,
umls-concept:C0181586,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0221099,
umls-concept:C0332294,
umls-concept:C0542341,
umls-concept:C1415585,
umls-concept:C2911684
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2005-3-8
|
|
pubmed:abstractText |
HIV has evolved several strategies to evade recognition by the host immune system including down-regulation of major histocompatibility complex (MHC) class I molecules. However, reduced expression of MHC class I molecules may stimulate natural killer (NK) cell lysis in cells of haematopoietic lineage. Here, we describe how HIV counteracts stimulation of NK cells by stabilizing surface expression of the non-classical MHC class I molecule, HLA-E. We demonstrate enhanced expression of HLA-E on lymphocytes from HIV-infected patients and show that in vitro infection of lymphocytes with HIV results in up-regulation of HLA-E expression and reduced susceptibility to NK cell cytotoxicity. Using HLA-E transfected K-562 cells, we identified the well-known HIV T-cell epitope p24 aa14-22a as a ligand for HLA-E that stabilizes surface expression of HLA-E, favouring inhibition of NK cell cytotoxicity. These results propose HIV-mediated up-regulation of HLA-E expression as an additional evasion strategy targeting the antiviral activities of NK cells, which may contribute to the capability of the virus in establishing chronic infection.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Core Protein p24,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-E antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell,
http://linkedlifedata.com/resource/pubmed/chemical/TAP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TAP2 protein, human
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1359-6535
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
95-107
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:15751767-ATP-Binding Cassette Transporters,
pubmed-meshheading:15751767-Amino Acid Sequence,
pubmed-meshheading:15751767-Antigens, CD,
pubmed-meshheading:15751767-Base Sequence,
pubmed-meshheading:15751767-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15751767-Case-Control Studies,
pubmed-meshheading:15751767-Cytotoxicity, Immunologic,
pubmed-meshheading:15751767-DNA,
pubmed-meshheading:15751767-Epitopes,
pubmed-meshheading:15751767-HIV Core Protein p24,
pubmed-meshheading:15751767-HIV Infections,
pubmed-meshheading:15751767-HIV-1,
pubmed-meshheading:15751767-HLA Antigens,
pubmed-meshheading:15751767-Histocompatibility Antigens Class I,
pubmed-meshheading:15751767-Humans,
pubmed-meshheading:15751767-K562 Cells,
pubmed-meshheading:15751767-Killer Cells, Natural,
pubmed-meshheading:15751767-Lectins, C-Type,
pubmed-meshheading:15751767-Ligands,
pubmed-meshheading:15751767-Molecular Sequence Data,
pubmed-meshheading:15751767-NK Cell Lectin-Like Receptor Subfamily D,
pubmed-meshheading:15751767-RNA, Messenger,
pubmed-meshheading:15751767-Receptors, Immunologic,
pubmed-meshheading:15751767-Receptors, Natural Killer Cell,
pubmed-meshheading:15751767-Transfection,
pubmed-meshheading:15751767-Up-Regulation
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.
|
|
pubmed:affiliation |
Department of Internal Medicine I, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany. Jacob.Nattermann@ukb.uni-bonn.de
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
