15750624

Source:http://linkedlifedata.com/resource/pubmed/id/15750624

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0079419, umls-concept:C1153410, umls-concept:C1182610, umls-concept:C1314939, umls-concept:C1879547
pubmed:issue	18
pubmed:dateCreated	2005-4-22
pubmed:abstractText	Recent studies from our lab found that ultraviolet (UV) irradiation induces a voltage-gated potassium (Kv) channel activation and subsequently activates JNK signaling pathway resulting in apoptosis. The present study in rabbit corneal epithelial (RCE) cells is to investigate mechanisms of UV irradiation-induced Kv channel activity involving p53 activation in parallel to DNA damage-induced signaling pathway. UV irradiation-induced signaling events were characterized by measurements of JNK activation and further downstream p53 phosphorylation. UV irradiation elicited an early response in the cell membrane through activation of Kv channels to activate the JNK signaling pathway and p53 phosphorylation. Exposure of RCE cells to UV irradiation within a few min resulted in JNK and p53 activations that were markedly inhibited by suppression of Kv channel activity. However, suppression of Kv channel activity failed to prevent p53 activation induced by extended DNA damages through prolonging UV exposure time (more than 15 min). In addition, caffeine inhibited UV-induced activation of SEK, an upstream MAPK kinase of JNK, resulting in suppression of both Kv channel-involved and DNA damage-induced p53 activation. Our results indicate in these cells that UV irradiation induces earlier and later intracellular events that link to activation of JNK and p53. The early event in response to UV irradiation is initiated by activating Kv channels in the cell membrane, and the later event is predominated by UV irradiation-caused DNA damage.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA 79229, http://linkedlifedata.com/resource/pubmed/grant/EY12953, http://linkedlifedata.com/resource/pubmed/grant/EY15282, http://linkedlifedata.com/resource/pubmed/grant/R01 CA074229-10, http://linkedlifedata.com/resource/pubmed/grant/R01 EY012953-05, http://linkedlifedata.com/resource/pubmed/grant/R01 EY015281-03
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8711562
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0950-9232
pubmed:author	pubmed-author:JayMM, pubmed-author:RohJ RJR, pubmed-author:WangLingL
pubmed:issnType	Print
pubmed:day	21
pubmed:volume	24
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3020-7
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:15750624-Animals, pubmed-meshheading:15750624-DNA, pubmed-meshheading:15750624-Epithelium, Corneal, pubmed-meshheading:15750624-Phosphorylation, pubmed-meshheading:15750624-Potassium Channels, pubmed-meshheading:15750624-Rabbits, pubmed-meshheading:15750624-Tumor Suppressor Protein p53, pubmed-meshheading:15750624-Ultraviolet Rays
pubmed:year	2005
pubmed:articleTitle	Ultraviolet irradiation-induced K(+) channel activity involving p53 activation in corneal epithelial cells.
pubmed:affiliation	Division of Molecular Medicine, Harbor-UCLA Medical Center, School of Medicine, University of California Los Angeles, Torrance, CA 90502, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S.