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rdf:type |
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lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0019704,
umls-concept:C0032105,
umls-concept:C0205419,
umls-concept:C0205466,
umls-concept:C0332281,
umls-concept:C0439831,
umls-concept:C0441889,
umls-concept:C0525005,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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|
pubmed:issue |
4
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pubmed:dateCreated |
2005-3-7
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|
pubmed:abstractText |
The multidrug-resistance transporter gene (MDR1) encoding for P-glycoprotein (P-gp) and genes encoding for isoenzymes of cytochrome P450 (CYP) have an important role in transport and metabolism of antiretroviral agents. This research examined the impact of single nucleotide polymorphisms (SNP) of MDR1 and CYP genes on nelfinavir and efavirenz pharmacokinetics and the response to highly active antiretroviral therapy (HAART) in HIV-1 infected children.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0269-9370
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
371-80
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15750390-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:15750390-CD4 Lymphocyte Count,
pubmed-meshheading:15750390-Child,
pubmed-meshheading:15750390-Child, Preschool,
pubmed-meshheading:15750390-Cytochrome P-450 Enzyme System,
pubmed-meshheading:15750390-Female,
pubmed-meshheading:15750390-Genes, MDR,
pubmed-meshheading:15750390-Genotype,
pubmed-meshheading:15750390-HIV Infections,
pubmed-meshheading:15750390-HIV Protease Inhibitors,
pubmed-meshheading:15750390-HIV-1,
pubmed-meshheading:15750390-Humans,
pubmed-meshheading:15750390-Male,
pubmed-meshheading:15750390-Nelfinavir,
pubmed-meshheading:15750390-Polymorphism, Single Nucleotide,
pubmed-meshheading:15750390-RNA, Viral,
pubmed-meshheading:15750390-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children.
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pubmed:affiliation |
Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093-0672, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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