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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-4
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pubmed:abstractText |
EP2 was identified as the major PGE2 receptor expressed in articular cartilage. An EP2 agonist increased intracellular cAMP in articular chondrocytes, stimulating DNA synthesis in both monolayer and 3D cultures. Hence, the EP2 agonist may be a potent therapeutic agent for degenerative cartilage diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Oxytocics,
http://linkedlifedata.com/resource/pubmed/chemical/PTGER2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ptger2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ptger2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP2...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0884-0431
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pubmed:author |
pubmed-author:AoyamaTomokiT,
pubmed-author:IshibeTatsuyaT,
pubmed-author:LiangBojianB,
pubmed-author:MatsusakiTakashiT,
pubmed-author:NagayamaSatoshiS,
pubmed-author:NakamuraTakashiT,
pubmed-author:NakayamaTomitakaT,
pubmed-author:NishijoKoichiK,
pubmed-author:OkamotoTakeshiT,
pubmed-author:ToguchidaJunyaJ,
pubmed-author:YasuraKoK
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
377-89
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15746982-Adult,
pubmed-meshheading:15746982-Aged,
pubmed-meshheading:15746982-Animals,
pubmed-meshheading:15746982-Cartilage, Articular,
pubmed-meshheading:15746982-Cell Line,
pubmed-meshheading:15746982-Cell Proliferation,
pubmed-meshheading:15746982-Child,
pubmed-meshheading:15746982-Chondrocytes,
pubmed-meshheading:15746982-Dinoprostone,
pubmed-meshheading:15746982-Female,
pubmed-meshheading:15746982-Gene Expression Regulation,
pubmed-meshheading:15746982-Humans,
pubmed-meshheading:15746982-Male,
pubmed-meshheading:15746982-Mice,
pubmed-meshheading:15746982-Oxytocics,
pubmed-meshheading:15746982-Rats,
pubmed-meshheading:15746982-Receptors, Prostaglandin E,
pubmed-meshheading:15746982-Receptors, Prostaglandin E, EP2 Subtype,
pubmed-meshheading:15746982-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
PGE2 signal through EP2 promotes the growth of articular chondrocytes.
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pubmed:affiliation |
Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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