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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-3-31
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pubmed:abstractText |
Advanced age is associated with a decrease in brain plasticity compared with the young adult. Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor promotes brain plasticity and improves functional outcome after stroke in the young animal. Here, we test the hypothesis that sildenafil provides restorative therapeutic benefit to the aged animal.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-GMP Phosphodiesterases,
http://linkedlifedata.com/resource/pubmed/chemical/Bromodeoxyuridine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide...,
http://linkedlifedata.com/resource/pubmed/chemical/Pde5a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Diester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/Synaptophysin,
http://linkedlifedata.com/resource/pubmed/chemical/sildenafil
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
847-52
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15746452-3',5'-Cyclic-GMP Phosphodiesterases,
pubmed-meshheading:15746452-Aging,
pubmed-meshheading:15746452-Animals,
pubmed-meshheading:15746452-Bromodeoxyuridine,
pubmed-meshheading:15746452-Cell Proliferation,
pubmed-meshheading:15746452-Cyclic GMP,
pubmed-meshheading:15746452-Cyclic Nucleotide Phosphodiesterases, Type 5,
pubmed-meshheading:15746452-Disease Models, Animal,
pubmed-meshheading:15746452-Endothelium, Vascular,
pubmed-meshheading:15746452-Immunohistochemistry,
pubmed-meshheading:15746452-Male,
pubmed-meshheading:15746452-Neovascularization, Pathologic,
pubmed-meshheading:15746452-Neuronal Plasticity,
pubmed-meshheading:15746452-Phosphodiesterase Inhibitors,
pubmed-meshheading:15746452-Phosphoric Diester Hydrolases,
pubmed-meshheading:15746452-Piperazines,
pubmed-meshheading:15746452-Purines,
pubmed-meshheading:15746452-Rats,
pubmed-meshheading:15746452-Rats, Wistar,
pubmed-meshheading:15746452-Sodium Chloride,
pubmed-meshheading:15746452-Stroke,
pubmed-meshheading:15746452-Sulfones,
pubmed-meshheading:15746452-Synapses,
pubmed-meshheading:15746452-Synaptophysin,
pubmed-meshheading:15746452-Time Factors,
pubmed-meshheading:15746452-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor.
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pubmed:affiliation |
Department of Neurology, Henry Ford Health Sciences Center, Detroit, Mich, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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