Source:http://linkedlifedata.com/resource/pubmed/id/15746259
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2005-5-17
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pubmed:abstractText |
Ghrelin is an acylated peptide hormone secreted primarily from endocrine cells in the stomach. The major active form of ghrelin is a 28-amino acid peptide with an n-octanoyl modification at Ser(3) (n-octanoyl ghrelin), which is essential for its activity. In addition to n-octanoyl ghrelin, other forms of ghrelin peptide exist, including des-acyl ghrelin, which lacks an acyl modification, and other minor acylated ghrelin species, such as n-decanoyl ghrelin, whose Ser(3) residue is modified by n-decanoic acid. Multiple reports have identified various physiological functions of ghrelin. However, until now, there have been no reports that explore the process of ghrelin acyl modification, and only a few studies have compared the levels of des-acyl, n-octanoyl, and/or other minor populations of acylated ghrelin peptides. In this study we report that the amount of n-octanoyl ghrelin in murine stomachs increases gradually during the suckling period to a maximal level at 3 wk of age and falls sharply after the initiation of weaning. However, the concentration (picomoles per milligram of wet weight tissue) of total ghrelin, which includes des-acyl and all acylated forms of ghrelin peptides with intact C termini in murine stomach, remains unchanged across this suckling-weaning transition. Prematurely weaned mice exhibited a significant decrease in the amount of n-octanoyl or n-decanoyl ghrelin in the stomach. Orally ingested glyceryl trioctanoate, a medium-chain triacylglyceride rich in milk lipids, significantly increased the level of n-octanoyl-modified ghrelin in murine stomach. Fluctuations in the proportion of this biologically active, acyl-modified ghrelin could contribute to or be influenced by the change in energy metabolism during the suckling-weaning transition.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Ghrelin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/ghrelin, des-n-octanoyl
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0013-7227
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2709-15
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15746259-Acylation,
pubmed-meshheading:15746259-Age Factors,
pubmed-meshheading:15746259-Animals,
pubmed-meshheading:15746259-Animals, Suckling,
pubmed-meshheading:15746259-Dietary Fats,
pubmed-meshheading:15746259-Energy Metabolism,
pubmed-meshheading:15746259-Ghrelin,
pubmed-meshheading:15746259-Male,
pubmed-meshheading:15746259-Mice,
pubmed-meshheading:15746259-Mice, Inbred C57BL,
pubmed-meshheading:15746259-Milk,
pubmed-meshheading:15746259-Peptide Hormones,
pubmed-meshheading:15746259-Rats,
pubmed-meshheading:15746259-Rats, Wistar,
pubmed-meshheading:15746259-Stomach,
pubmed-meshheading:15746259-Triglycerides,
pubmed-meshheading:15746259-Weaning
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pubmed:year |
2005
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pubmed:articleTitle |
Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrelins in murine stomach.
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pubmed:affiliation |
Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Fukuoka 839-0861, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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