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rdf:type |
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lifeskim:mentions |
umls-concept:C0006935,
umls-concept:C0016452,
umls-concept:C0030705,
umls-concept:C0123931,
umls-concept:C0201734,
umls-concept:C0205390,
umls-concept:C0280100,
umls-concept:C0331858,
umls-concept:C0442027,
umls-concept:C1280500,
umls-concept:C1442162,
umls-concept:C1550718,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C1720454,
umls-concept:C2332784,
umls-concept:C2603343
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pubmed:issue |
4
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pubmed:dateCreated |
2005-3-4
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pubmed:abstractText |
To characterize the maximum-tolerated dose, recommended dose, dose-limiting toxicities (DLT), pharmacokinetic profile, and food effect of orally administered irinotecan formulated as new semisolid matrix capsules.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Camptothecin,
http://linkedlifedata.com/resource/pubmed/chemical/Capsules,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/bilirubin...,
http://linkedlifedata.com/resource/pubmed/chemical/irinotecan
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AssadourianSylvieS,
pubmed-author:DumezHerlindeH,
pubmed-author:EskensFerry A L MFA,
pubmed-author:LefebvrePatriciaP,
pubmed-author:SanderinkGer-JanGJ,
pubmed-author:SelleslachJohanJ,
pubmed-author:SoepenbergOttoO,
pubmed-author:SparreboomAlexA,
pubmed-author:Ter SteegJudithJ,
pubmed-author:ThomasJoséJ,
pubmed-author:VerweijJaapJ,
pubmed-author:de JongFloris AFA,
pubmed-author:de JongeMaja J AMJ,
pubmed-author:van OosteromAllan TAT,
pubmed-author:van SchaikRon H NRH
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1504-11
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15746053-Administration, Oral,
pubmed-meshheading:15746053-Adult,
pubmed-meshheading:15746053-Aged,
pubmed-meshheading:15746053-Anemia,
pubmed-meshheading:15746053-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:15746053-Area Under Curve,
pubmed-meshheading:15746053-Camptothecin,
pubmed-meshheading:15746053-Capsules,
pubmed-meshheading:15746053-Cytochrome P-450 CYP3A,
pubmed-meshheading:15746053-Cytochrome P-450 Enzyme System,
pubmed-meshheading:15746053-Diarrhea,
pubmed-meshheading:15746053-Dietary Fats,
pubmed-meshheading:15746053-Dose-Response Relationship, Drug,
pubmed-meshheading:15746053-Drug Administration Schedule,
pubmed-meshheading:15746053-Female,
pubmed-meshheading:15746053-Genotype,
pubmed-meshheading:15746053-Glucuronosyltransferase,
pubmed-meshheading:15746053-Humans,
pubmed-meshheading:15746053-Leukopenia,
pubmed-meshheading:15746053-Male,
pubmed-meshheading:15746053-Middle Aged,
pubmed-meshheading:15746053-Nausea,
pubmed-meshheading:15746053-Neoplasms,
pubmed-meshheading:15746053-Neutropenia,
pubmed-meshheading:15746053-Polymorphism, Genetic,
pubmed-meshheading:15746053-Promoter Regions, Genetic,
pubmed-meshheading:15746053-Thrombocytopenia,
pubmed-meshheading:15746053-Time Factors,
pubmed-meshheading:15746053-Treatment Outcome,
pubmed-meshheading:15746053-Vomiting
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pubmed:year |
2005
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pubmed:articleTitle |
Phase I pharmacokinetic, food effect, and pharmacogenetic study of oral irinotecan given as semisolid matrix capsules in patients with solid tumors.
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pubmed:affiliation |
Daniel den Hoed Cancer Center, Department of Medical Oncology, Erasmus University Medical Center Rotterdam, Groene Hilledijk 301, 3075 EA Rotterdam, the Netherlands. o.soepenberg@erasmusmc.nl
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Clinical Trial, Phase I
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