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rdf:type |
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lifeskim:mentions |
umls-concept:C0003232,
umls-concept:C0018270,
umls-concept:C0021469,
umls-concept:C0022702,
umls-concept:C0025252,
umls-concept:C0039476,
umls-concept:C0085490,
umls-concept:C0086045,
umls-concept:C0317578,
umls-concept:C0441889,
umls-concept:C1167331,
umls-concept:C1171362,
umls-concept:C1280500
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pubmed:issue |
1
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pubmed:dateCreated |
2005-3-4
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pubmed:abstractText |
The objective of this study was to determine the effects of sub-minimum inhibitory concentrations (sub-MICs) of 2 veterinary antibiotic preparations, chlortetracycline (CTC) and chlortetracycline-sulfamethazine (CTC + SMZ), on growth kinetics and outer membrane protein expression in Mannheimia haemolytica and Haemophilus somnus at normal and febrile body temperatures. Sub-minimum inhibitory concentrations of both antibiotics reduced the growth rates of M. haemolytica and H. somnus. Growth of both species was not inhibited when grown at 41 degrees C compared to 37 degrees C. There was no detectable consistent effect of antibiotic or temperature on outer membrane protein expression for either species. Our study indicates that sub-MIC levels of CTC and CTC + SMZ markedly impair growth of clinical M. haemolytica and H. somnus isolates, potentially allowing more effective host clearance during infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-10417136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-10461841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-10504701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-1058727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-11724833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-1444290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-1645128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-1646768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-1689127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-1783910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-1789515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-2391489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-2843469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-3570472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-396634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-6186688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-6205995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-7042209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-7600512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-7881547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-8031095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-819413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-8418069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-8478064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-8870193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-9058546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-9595628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15745216-9659550
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0830-9000
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15745216-Anti-Bacterial Agents,
pubmed-meshheading:15745216-Bacterial Outer Membrane Proteins,
pubmed-meshheading:15745216-Chlortetracycline,
pubmed-meshheading:15745216-Drug Therapy, Combination,
pubmed-meshheading:15745216-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:15745216-Gene Expression Regulation, Bacterial,
pubmed-meshheading:15745216-Haemophilus somnus,
pubmed-meshheading:15745216-Kinetics,
pubmed-meshheading:15745216-Mannheimia haemolytica,
pubmed-meshheading:15745216-Microbial Sensitivity Tests,
pubmed-meshheading:15745216-Sulfamethazine,
pubmed-meshheading:15745216-Temperature
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pubmed:year |
2005
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pubmed:articleTitle |
Effects of sub-minimum inhibitory concentration antibiotic levels and temperature on growth kinetics and outer membrane protein expression in Mannheimia haemolytica and Haemophilus somnus.
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pubmed:affiliation |
College of Veterinary Medicine, Mississippi State University, Mississippi 39762, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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