Linked Life Data

15744

Source:http://linkedlifedata.com/resource/pubmed/id/15744

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1977-6-30
pubmed:abstractText
This and previous papers examine the reasons for the relationship between the concentrations of guanidino-succinate and guanidinoacetate in human urine. With the demonstration here that extracts of human liver-tissue can mediate ureidohomoserine formation from canaline [(2-amino-4-aminooxy)-butyric acid] and carbamoyl phosphate, all steps in a cycle proposed for the production of guanidinoacetate and guanidinosuccinate have been documented. This includes synthesis of canavaninosuccinate from aspartate and ureidohomoserine, reductive cleavage of canavaninosuccinate to form guanidinosuccinate and homoserine, or, alternatively, lytic action on canavaninosuccinate to form fumarate and canavanine, and transamidination to glycine to form guanidinoacetate, regenerating the canaline. We propose that canaline originates from aspartate, but the precise mechanism by which canaline is formed needs to be elucidated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-9147
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
960-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Canaline carbamoyltransferase in human liver as part of a metabolic cycle in which guanidino compounds are formed.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.