Linked Life Data

15744341

Source:http://linkedlifedata.com/resource/pubmed/id/15744341

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pubmed-article:15744341pubmed:abstractTextTwo microarray studies of mediastinal B cell lymphoma have shown that this disease has a distinct gene expression profile, and also that this is closest to the pattern seen in classical Hodgkin's disease. We reported previously an immunohistologic study in which the loss of intracellular B cell-associated signaling molecules in Reed-Sternberg cells was demonstrated, and in this study we have investigated the expression of the same components in more than 60 mediastinal B cell lymphomas. We report that these signaling molecules are frequently present, and in particular that Syk, BLNK and PLC-gamma2 (absent from Reed-Sternberg cells) are present in the majority of mediastinal B cell lymphomas. The overall pattern of B cell signaling molecules in this disease is therefore closer to that of diffuse large B cell lymphoma than to Hodgkin's disease, and is consistent with a common cell of origin as an explanation of the similar gene expression profiles.lld:pubmed
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pubmed-article:15744341pubmed:articleTitleExpression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma.lld:pubmed
pubmed-article:15744341pubmed:affiliationLeukaemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK. teresa.marafioti@ndcls.ox.ac.uklld:pubmed
pubmed-article:15744341pubmed:publicationTypeJournal Articlelld:pubmed
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