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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-4-26
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pubmed:abstractText |
Two microarray studies of mediastinal B cell lymphoma have shown that this disease has a distinct gene expression profile, and also that this is closest to the pattern seen in classical Hodgkin's disease. We reported previously an immunohistologic study in which the loss of intracellular B cell-associated signaling molecules in Reed-Sternberg cells was demonstrated, and in this study we have investigated the expression of the same components in more than 60 mediastinal B cell lymphomas. We report that these signaling molecules are frequently present, and in particular that Syk, BLNK and PLC-gamma2 (absent from Reed-Sternberg cells) are present in the majority of mediastinal B cell lymphomas. The overall pattern of B cell signaling molecules in this disease is therefore closer to that of diffuse large B cell lymphoma than to Hodgkin's disease, and is consistent with a common cell of origin as an explanation of the similar gene expression profiles.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/B cell linker protein,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/NFATC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipase C gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Syk kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases,
http://linkedlifedata.com/resource/pubmed/chemical/lyn protein-tyrosine kinase,
http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0887-6924
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pubmed:author |
pubmed-author:CAMUSPP,
pubmed-author:Copie-BergmanCC,
pubmed-author:GascoyneR DRD,
pubmed-author:GaulardPP,
pubmed-author:HansmannM-LML,
pubmed-author:LowP SPS,
pubmed-author:MöllerPP,
pubmed-author:MarafiotiTT,
pubmed-author:Martín-SuberoJ IJI,
pubmed-author:MasonD YDY,
pubmed-author:NatkunamYY,
pubmed-author:PileriS ASA,
pubmed-author:PozzobonMM,
pubmed-author:RobertonHH,
pubmed-author:SiebertRR,
pubmed-author:VenturaRR
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
856-61
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:15744341-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15744341-Blotting, Western,
pubmed-meshheading:15744341-Carrier Proteins,
pubmed-meshheading:15744341-DNA-Binding Proteins,
pubmed-meshheading:15744341-Enzyme Precursors,
pubmed-meshheading:15744341-Hodgkin Disease,
pubmed-meshheading:15744341-Humans,
pubmed-meshheading:15744341-Immunohistochemistry,
pubmed-meshheading:15744341-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15744341-Lymphoma, B-Cell,
pubmed-meshheading:15744341-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:15744341-Mediastinal Neoplasms,
pubmed-meshheading:15744341-NFATC Transcription Factors,
pubmed-meshheading:15744341-Nuclear Proteins,
pubmed-meshheading:15744341-Phospholipase C gamma,
pubmed-meshheading:15744341-Phosphoproteins,
pubmed-meshheading:15744341-Protein-Tyrosine Kinases,
pubmed-meshheading:15744341-Signal Transduction,
pubmed-meshheading:15744341-Transcription Factors,
pubmed-meshheading:15744341-Type C Phospholipases,
pubmed-meshheading:15744341-src-Family Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma.
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pubmed:affiliation |
Leukaemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK. teresa.marafioti@ndcls.ox.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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