Source:http://linkedlifedata.com/resource/pubmed/id/15744337
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2005-4-26
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| pubmed:abstractText |
Kaposi sarcoma-associated herpesvirus (KSHV) is known to be associated with two distinct lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD)/MCD-associated plasmablastic lymphoma. We here report a high incidence of KSHV infection in solid HIV-associated immunoblastic/plasmablastic non-Hodgkin's lymphomas (NHLs), in patients lacking effusions and without evidence of (prior) MCD. Within a cohort of 99 HIV-related NHLs, 10 cases were found to be KSHV positive on the basis of immunostaining for KSHV LNA-1 as well as KSHV-specific polymerase chain reaction. All but one of the tumors coexpressed Epstein-Barr virus. Interestingly, all KSHV-positive cases belonged to a distinctive subgroup of 26 diffuse large B-cell lymphomas characterized by the expression of CD138 (syndecan-1) and plasmablastic/immunoblastic morphology. These KSHV-positive lymphomas were preceded by Kaposi sarcoma in 60% of the patients and involved the gastrointestinal tract in 80%. Our results indicate that KSHV infection is not restricted to PEL and MCD; it is also common (38%) in HIV-related solid immunoblastic/plasmablastic lymphomas.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0887-6924
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
851-5
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15744337-Adult,
pubmed-meshheading:15744337-Cohort Studies,
pubmed-meshheading:15744337-Comorbidity,
pubmed-meshheading:15744337-Female,
pubmed-meshheading:15744337-Giant Lymph Node Hyperplasia,
pubmed-meshheading:15744337-HIV Infections,
pubmed-meshheading:15744337-Herpesviridae Infections,
pubmed-meshheading:15744337-Herpesvirus 8, Human,
pubmed-meshheading:15744337-Humans,
pubmed-meshheading:15744337-Immunohistochemistry,
pubmed-meshheading:15744337-Immunophenotyping,
pubmed-meshheading:15744337-Incidence,
pubmed-meshheading:15744337-Lymphoma, AIDS-Related,
pubmed-meshheading:15744337-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:15744337-Male,
pubmed-meshheading:15744337-Middle Aged,
pubmed-meshheading:15744337-Netherlands,
pubmed-meshheading:15744337-Sarcoma, Kaposi
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
High incidence of Kaposi sarcoma-associated herpesvirus infection in HIV-related solid immunoblastic/plasmablastic diffuse large B-cell lymphoma.
|
| pubmed:affiliation |
Department of Pathology Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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| pubmed:publicationType |
Journal Article
|