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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-3-3
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pubmed:abstractText |
Human Fas-associated factor 1 (hFAF1) is a novel protein having multiubiquitin-related domains. We investigated the cellular functions of hFAF1 and found that valosin-containing protein (VCP), the multiubiquitin chain-targeting factor in the degradation of the ubiquitin-proteasome pathway, is a binding partner of hFAF1. hFAF1 is associated with the ubiquitinated proteins via the newly identified N-terminal UBA domain and with VCP via the C-terminal UBX domain. The overexpression of hFAF1 and a truncated UBA domain inhibited the degradation of ubiquitinated proteins and increased cell death. These results suggest that hFAF1 binding to ubiquitinated protein and VCP is involved in the ubiquitin-proteasome pathway. We hypothesize that hFAF1 may serve as a scaffolding protein that regulates protein degradation in the ubiquitin-proteasome pathway.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-10089879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-10381632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-10462485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-10802622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-10811609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-11243799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-11478859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-11483959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-11583613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-11584278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-11740563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-11805328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-11882310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-11980917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12015140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12052895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12079361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12391322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12411482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12643283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12702723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12724336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12944474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-12947384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-14600157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-15117949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-15242647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-6749598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-7615550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-8524870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-8702753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-8871400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-8890162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-9214505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-9257699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-9452483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-9506515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-9683630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-9759494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15743842-9859996
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/CDC48 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FAF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Leupeptins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin,
http://linkedlifedata.com/resource/pubmed/chemical/benzyloxycarbonylleucyl-leucyl-leuci...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2511-24
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15743842-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15743842-Adenosine Triphosphatases,
pubmed-meshheading:15743842-Amino Acid Sequence,
pubmed-meshheading:15743842-Apoptosis,
pubmed-meshheading:15743842-Carrier Proteins,
pubmed-meshheading:15743842-Cell Cycle Proteins,
pubmed-meshheading:15743842-Cell Line,
pubmed-meshheading:15743842-Cytosol,
pubmed-meshheading:15743842-Humans,
pubmed-meshheading:15743842-I-kappa B Proteins,
pubmed-meshheading:15743842-Leupeptins,
pubmed-meshheading:15743842-Molecular Sequence Data,
pubmed-meshheading:15743842-Proteasome Endopeptidase Complex,
pubmed-meshheading:15743842-Protein Structure, Tertiary,
pubmed-meshheading:15743842-Tumor Necrosis Factor-alpha,
pubmed-meshheading:15743842-Ubiquitin
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pubmed:year |
2005
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pubmed:articleTitle |
Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway.
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pubmed:affiliation |
Center for Cell Signaling Research, Division of Molecular Life Sciences and College of Pharmacy, Ewha Womans University, Seoul 120-750, South Korea.
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