|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2005-3-3
|
|
pubmed:abstractText |
A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of (99m)Tc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of pre-osteoclasts to functional osteoclasts induced by receptor activator of NF-kappaB ligand (RANKL), through a prevalent NO-dependent mechanism.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Diphosphonates,
http://linkedlifedata.com/resource/pubmed/chemical/Durapatite,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Radiopharmaceuticals,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Pertechnetate Tc 99m,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf11 protein, mouse
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
10
|
|
pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1322-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15743175-Animals,
pubmed-meshheading:15743175-Bone Resorption,
pubmed-meshheading:15743175-Carrier Proteins,
pubmed-meshheading:15743175-Cell Differentiation,
pubmed-meshheading:15743175-Cell Line,
pubmed-meshheading:15743175-Diphosphonates,
pubmed-meshheading:15743175-Durapatite,
pubmed-meshheading:15743175-Male,
pubmed-meshheading:15743175-Membrane Glycoproteins,
pubmed-meshheading:15743175-Mice,
pubmed-meshheading:15743175-NF-kappa B,
pubmed-meshheading:15743175-Nitric Oxide Donors,
pubmed-meshheading:15743175-Osteoclasts,
pubmed-meshheading:15743175-RANK Ligand,
pubmed-meshheading:15743175-Radiopharmaceuticals,
pubmed-meshheading:15743175-Rats,
pubmed-meshheading:15743175-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:15743175-Sodium Pertechnetate Tc 99m,
pubmed-meshheading:15743175-Stem Cells,
pubmed-meshheading:15743175-Structure-Activity Relationship,
pubmed-meshheading:15743175-Tissue Distribution
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption.
|
|
pubmed:affiliation |
Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125 Turin, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
