Linked Life Data

15742355

Source:http://linkedlifedata.com/resource/pubmed/id/15742355

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2005-3-8
pubmed:abstractText
The EtOH extract from the rhizomes of Astilbe chinensis (Saxifragaceae) exhibited potent antioxidant activity in preliminary screening. Since oxidative stress is known to be involved in the inflammatory response after UVB exposure, the ability of an A. chinensis extract to inhibit UVB-induced PGE2 and NO production was examined. UVB irradiation (35 mJ/cm2) increased PGE2 and NO production, which were significantly decreased by pre-administration of the extract in a dose-dependent manner. The A. chinensis extract also preserved the cellular antioxidant capacity after UVB irradiation, which was determined by the GSH content. UVB irradiation enhanced the formation of ROS in the keratinocytes, which was determined using DCFH-DA, a redox sensitive dye. The levels of intracellular ROS were also significantly reduced by pre-treatment of the extract in a dose-dependent manner measured 9 h after UVB irradiation. The results suggest that the A. chinensis extract may have a protective effect on the UVB-injured keratinocytes by inhibiting PGE2 and NO production, possibly through the inhibition of intracellular ROS accumulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0951-418X
pubmed:author
pubmed:copyrightInfo
2004 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1000-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Effect of the rhizomes of Astilbe chinensis on UVB-induced inflammatory response.
pubmed:affiliation
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't