Linked Life Data

15740804

Source:http://linkedlifedata.com/resource/pubmed/id/15740804

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-3-2
pubmed:abstractText
The hippocampus is involved in the encoding, storage, and retrieval of memory. Here, we have developed a novel mapping method for detecting the distribution of neural activity of the entire population of pyramidal cells in the hippocampal CA1 and subiculum regions, where expression profiles of Arc mRNA were used as an indicator of neural activity. The spherical pyramidal cell layer of the intact hippocampus was flattened into a two-dimensional plane, which was then serially sectioned in parallel with the plane to make tangential sections. Tangential sections were hybridized with an Arc cRNA probe and Arc signals from serial tangential sections were stacked and displayed on a two-dimensional plane, allowing one to easily visualize the neural activity of all pyramidal cells. We applied this method to the hippocampus of rats that had experienced contextual fear conditioning, which requires hippocampal function. We observed a net shift of Arc signals from dorsal to ventral CA1/subiculum with an interval prolongation to reconditioning after the initial conditioning. The reconditioning-revealed shift may reflect a reorganization process, which takes place during the period between initial conditioning and reconditioning, in the CA1/subiculum neural network that represents the neural storage and/or retrieval of the contextual fear conditioning.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0168-0102
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
417-25
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Two-dimensional neural activity mapping of the entire population of hippocampal CA1 pyramidal cells responding to fear conditioning.
pubmed:affiliation
Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya, Machida, Tokyo 194-8511, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't