Linked Life Data

15739237

Source:http://linkedlifedata.com/resource/pubmed/id/15739237

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-3-7
pubmed:abstractText
We investigated the spatial relationship of axonal and dendritic structures in the rat pontine nuclei (PN), which transfer visual signals from the superior colliculus (SC) and visual cortex (A17) to the cerebellum. Double anterograde tracing (DiI and DiAsp) from different sites in the SC showed that the tectal retinotopy of visual signals is largely lost in the PN. Whereas axon terminals from lateral sites in the SC were confined to a single terminal field close to the cerebral peduncle, medial sites in the SC projected to an additional dorsolateral one. On the other hand, axon terminals originating from the two structures occupy close but, nevertheless, totally nonoverlapping terminal fields within the PN. Furthermore, a quantitative analysis of the dendritic trees of intracellularly filled identified pontine projection neurons showed that the dendritic fields were confined to either the SC or the A17 terminal fields and never extended into both. We also investigated the projections carrying cortical somatosensory inputs to the PN as these signals are known to converge with tectal ones in the cerebellum. However, terminals originating in the whisker representation of the primary somatosensory cortex and in the SC were located in segregated pontine compartments as well. Our results, therefore, point to a possible pontocerebellar mapping rule: Functionally related signals, commonly destined for common cerebellar target zones but residing in different afferent locations, may be kept segregated on the level of the PN and converge only later at specific sites in the granular layer of cerebellar cortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 2005 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
484
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-98
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Organization of tectopontine terminals within the pontine nuclei of the rat and their spatial relationship to terminals from the visual and somatosensory cortex.
pubmed:affiliation
Abteilung für Kognitive Neurologie, Hertie-Institut für Klinische Hirnforschung, Universität Tübingen, 72076 Tübingen, Germany. cornelius.schwarz@uni-tuebingen.de
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't