Linked Life Data

15737877

Source:http://linkedlifedata.com/resource/pubmed/id/15737877

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-3-1
pubmed:abstractText
This review provides some basic information on chronic lymphocytic leukemia (CLL) and attempts to present some of the newer data which have accumulated in recent years including those relating to familial aggregation of CLL and the detection of monoclonal CD5+ lymphocytosis in the general population and families of CLL patients. Novel data on the pathogenesis and concepts of cell origin in CLL are also reviewed stressing the fact that there is biased IgVH gene usage, and the importance of mutational status of the CLL cell, as reported in recent years by different authors. A brief review of the significance of the microenvironmental interactions between stromal cells and other accessory cells, and the leukemic CLL cells is also provided. Other clinical aspects are discussed including diagnostic criteria, clinical staging, and the newer prognostic factors which influence survival and timing of therapy for CLL patients. We also attempt to outline the therapeutic options available and the principles of planning risk and age-adapted treatment, stressing the importance and the necessity for participating in ongoing and future international clinical trials.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
T
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1473-0502
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-97
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Chronic lymphocytic leukemia: a review of some new aspects of the biology, factors influencing prognosis and therapeutic options.
pubmed:affiliation
Department of Hematology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel. herishanu@yahoo.com
pubmed:publicationType
Journal Article, Review