Source:http://linkedlifedata.com/resource/pubmed/id/15736828
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2005-3-1
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| pubmed:abstractText |
Cisplatin an antineoplastic medicine, was incorporated into a silica gel received by the sol-gel method. Various techniques of trapping an active substance in gel were applied: at the stage of sol creation--by the predoping method--and already upon receipt of hard xerogel--the postdoping method. Further, the research aimed at the determination of the dynamics of cisplatin release from sol-gel processed silica xerogel to the water phase. Based on the achieved results, we may state that the sol-gel method is useful for trapping a medicine like cisplatin in silica gel and gives repeatable results with regard to medicine release from the pores of the so-established matrix. The postdoping method appeared to be more beneficial, because the gained gel's active substance is released almost entirely (94-96%). The time of release was 3 days.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1071-7544
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
11
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
341-4
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading | |
| pubmed:articleTitle |
In vitro release of cisplatin from sol-gel processed porous silica xerogels.
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| pubmed:affiliation |
Department of Physical Chemistry with Laboratory of Instrumental Analysis, Medical University of Gda?sk, al. Gen. J. Hallera 107, 80-416 Gda?sk, Poland. kczar@biology.pl
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| pubmed:publicationType |
Journal Article
|