rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-3-1
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pubmed:abstractText |
Twist, a transcription factor of the basic helix-loop-helix class, has been suggested to have oncogenic properties. We reported Twist expression was regulated by Wnt/beta-catenin signaling and that both Wnt-1 and Twist could contribute to mammary tumorigenesis. The aim of this study was to demonstrate the expression of Twist, Wnt-1 and Wnt-2 in human breast cancer tissue. We examined the expression in patients with breast cancer by RT-PCR and immunohistochemistry. RT-PCR of twenty-three pairs of cancer and normal breast tissue revealed that Twist was up-regulated in 69.6% (16/23) of the cancer lesions and 21.7% (5/23) of the normal breast tissues. Wnt-2 was up-regulated in all of the cancer lesions and 13.0% (3/23) of the normal breast tissues, whereas Wnt-1 was expressed in both the cancer and normal breast tissues of the five cases examined. Immunohistochemical analyses revealed that Twist was positively expressed in 52.2% (12/23) of the cancer lesions and 34.8% (8/23) of the normal breast tissues. Twist and Wnt-2 are highly expressed in breast cancer tissue, suggesting that both molecules could play important roles in mammary carcinogenesis.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TWIST1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Twist Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/WNT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/WNT2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt2 Protein
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3851-6
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15736421-Breast Neoplasms,
pubmed-meshheading:15736421-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15736421-Humans,
pubmed-meshheading:15736421-Immunohistochemistry,
pubmed-meshheading:15736421-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15736421-Nuclear Proteins,
pubmed-meshheading:15736421-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15736421-Transcription Factors,
pubmed-meshheading:15736421-Twist Transcription Factor,
pubmed-meshheading:15736421-Up-Regulation,
pubmed-meshheading:15736421-Wnt Proteins,
pubmed-meshheading:15736421-Wnt1 Protein,
pubmed-meshheading:15736421-Wnt2 Protein
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pubmed:articleTitle |
Expression of twist and wnt in human breast cancer.
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pubmed:affiliation |
Department of Surgery, Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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