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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1992-5-29
|
| pubmed:abstractText |
1-Amino-3-(aminooxy)-2-propanol (6a) has been synthesized and found to inhibit rat liver ornithine decarboxylase (ODC) with an IC50 in the nanomolar range. Compound 6a served as a basis for the design of new enzyme inhibitors, which led to the identification of 3-(aminooxy)-2-fluoropropanamine (15) as a new powerful enzyme blocker. Compound 15 inhibited ODC at 3 times lower concentrations than 6a and 3-(aminooxy)propanamine (APA), and it was superior to APA as an antiproliferative agent in inhibiting the growth of human T24 bladder carcinoma cells in vitro.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
17
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1339-44
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1573631-Animals,
pubmed-meshheading:1573631-Cell Division,
pubmed-meshheading:1573631-Diamines,
pubmed-meshheading:1573631-Enzyme Inhibitors,
pubmed-meshheading:1573631-Humans,
pubmed-meshheading:1573631-Liver,
pubmed-meshheading:1573631-Ornithine Decarboxylase,
pubmed-meshheading:1573631-Propanolamines,
pubmed-meshheading:1573631-Rats,
pubmed-meshheading:1573631-Structure-Activity Relationship,
pubmed-meshheading:1573631-Tumor Cells, Cultured
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity.
|
| pubmed:affiliation |
Research Laboratories, Pharmaceuticals Division, Ciba-Geigy AG., Basel, Switzerland.
|
| pubmed:publicationType |
Journal Article
|