Source:http://linkedlifedata.com/resource/pubmed/id/15736114
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2005-2-28
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pubmed:abstractText |
The metabolism of apolipoproteins (apo) (a) and B-100 within plasma lipoprotein (a) [Lp(a)] was examined in the fed state in 23 subjects aged 41 to 79 years who received a primed-constant infusion of [5,5,5-2H3] leucine over 15 hours. Lipoprotein (a) was isolated from the whole plasma using a lectin affinity-based method. Apolipoprotein (a) and apoB-100 were separated by gel electrophoresis, and tracer enrichment of each apolipoprotein was measured using gas chromatography/mass spectrometry. Data were fit to a multicompartmental model to determine fractional catabolic rates (FCRs) and secretion rates (SRs). The FCRs of apo(a) and apoB-100 (mean +/- SEM) within plasma Lp(a) were significantly different (0.220 +/- 0.030 pool/d and 0.416 +/- 0.040 pool/d, respectively; P < .001). Apolipoprotein (a) SR (0.50 +/- 0.08 mg/[kg per d]) was significantly lower than that of apoB-100 SR (1.53 +/- 0.22 mg/[kg per d]; P < .001) of Lp(a). Plasma concentrations of Lp(a) were correlated significantly with both apo(a) SR and apoB-100 SR (r = 0.837 and r = 0.789, respectively; P < .001) and negatively with apo(a) FCR and Lp(a) apoB-100 FCR (r = -0.547 and r = -0.717, respectively; P < .01). These data implicate different metabolic fates for apo(a) and apoB-100 within Lp(a) in the fed state. We therefore hypothesize that apo(a) does not remain covalently linked to a single apoB-100 lipoprotein but that it rather reassociates at least once with another apoB-100 particle, probably newly synthesized, during its plasma metabolism.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein B-100,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins A,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Deuterium,
http://linkedlifedata.com/resource/pubmed/chemical/Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoprotein(a)
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0026-0495
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pubmed:author |
pubmed-author:BarrettP Hugh RPH,
pubmed-author:DolnikowskiGregory GGG,
pubmed-author:JennerJennifer LJL,
pubmed-author:Lamon-FavaStefaniaS,
pubmed-author:LichtensteinAlice HAH,
pubmed-author:MarcovinaSantica MSM,
pubmed-author:MillarJohn SJS,
pubmed-author:SchaeferErnst JEJ,
pubmed-author:SemanLeo JLJ,
pubmed-author:WeltyFrancine KFK,
pubmed-author:deLucaCarlC
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15736114-Adult,
pubmed-meshheading:15736114-Aged,
pubmed-meshheading:15736114-Apolipoprotein B-100,
pubmed-meshheading:15736114-Apolipoproteins A,
pubmed-meshheading:15736114-Apolipoproteins B,
pubmed-meshheading:15736114-Deuterium,
pubmed-meshheading:15736114-Female,
pubmed-meshheading:15736114-Food,
pubmed-meshheading:15736114-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:15736114-Humans,
pubmed-meshheading:15736114-Kinetics,
pubmed-meshheading:15736114-Leucine,
pubmed-meshheading:15736114-Lipoprotein(a),
pubmed-meshheading:15736114-Male,
pubmed-meshheading:15736114-Middle Aged,
pubmed-meshheading:15736114-Regression Analysis
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pubmed:year |
2005
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pubmed:articleTitle |
The metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein (a) in human beings.
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pubmed:affiliation |
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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