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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-2-28
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pubmed:abstractText |
Tumor necrosis treatment (TNT) uses degenerating tumor cells and necrotic regions of tumors as targets for radioimmunotherapy. Previous studies in animal tumor models and clinical trials have demonstrated that when linked to the therapeutic radionuclide iodine-131, recombinant chimeric TNT antibody ((131)I-chTNT) can deliver therapeutic doses to tumors regardless of the location or type of malignancy. Therapeutic efficacy and toxicity of (131)I-chTNT in advanced lung cancer patients were studied in this pivotal registration trial.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:ChenShaoliangS,
pubmed-author:ChenYangchunY,
pubmed-author:EpsteinAlan LAL,
pubmed-author:FuQingQ,
pubmed-author:HuPeishengP,
pubmed-author:JiangChangyingC,
pubmed-author:JuDian WenDW,
pubmed-author:KhawliLeslie ALA,
pubmed-author:LiShenyuS,
pubmed-author:LiaoGuoqingG,
pubmed-author:RyuS SSS,
pubmed-author:TaylorClive RCR,
pubmed-author:VadHH,
pubmed-author:YeDanD,
pubmed-author:YuLikeL,
pubmed-author:ZhaoYanY
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1538-47
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15735129-Adult,
pubmed-meshheading:15735129-Aged,
pubmed-meshheading:15735129-Antibodies, Neoplasm,
pubmed-meshheading:15735129-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15735129-Female,
pubmed-meshheading:15735129-Humans,
pubmed-meshheading:15735129-Immunotoxins,
pubmed-meshheading:15735129-Iodine Radioisotopes,
pubmed-meshheading:15735129-Lung Neoplasms,
pubmed-meshheading:15735129-Male,
pubmed-meshheading:15735129-Middle Aged,
pubmed-meshheading:15735129-Necrosis,
pubmed-meshheading:15735129-Positron-Emission Tomography,
pubmed-meshheading:15735129-Radioimmunotherapy,
pubmed-meshheading:15735129-Tissue Distribution
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pubmed:year |
2005
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pubmed:articleTitle |
Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer.
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pubmed:affiliation |
Zhongshan Hospital and Tumor Hospital, Fudan University, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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