Linked Life Data

15735069

Source:http://linkedlifedata.com/resource/pubmed/id/15735069

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-2-28
pubmed:abstractText
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear transcription factor regulating multiple genes involved in lipid metabolism. It was shown that a common leucine to valine (L162V) substitution at the PPARalpha gene (PPARA) is functional and affects transactivation activity of PPARalpha ligands, such as PUFA, on a concentration-dependent basis. The current study examined this gene-nutrient interaction in relation to plasma lipid variables in a population-based study consisting of 1003 men and 1103 women participating in the Framingham cohort and consuming their habitual diets. We found significant gene-nutrient interactions between the L162V polymorphism and total PUFA intake, which modulated plasma triglycerides (TG; P < 0.05) and apolipoprotein C-III (apoC-III; P < 0.05) concentrations. The 162V allele was associated with greater TG and apoC-III concentrations only in subjects consuming a low-PUFA diet (below the population mean, 6% of energy). However, when PUFA intake was high, carriers of the 162V allele had lower apoC-III concentrations. This interaction was significant even when PUFA intake was considered as a continuous variable (P = 0.031 for TG and P < 0.001 for apoC-III), suggesting a strong dose-response effect. When PUFA intake was <4%, 162V allele carriers had approximately 28% higher plasma TG than did 162L homozygotes (P < 0.01). Conversely, when PUFA intake was >8%, plasma TG in 162V allele carriers was 4% lower than in 162L homozygotes. Similar results were obtained for (n-6) and (n-3) fatty acids. Our data show that the effect of the L162V polymorphism on plasma TG and apoC-III concentrations depends on the dietary PUFA, with a high intake triggering lower TG in carriers of the 162V allele.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
397-403
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15735069-Alcohol Drinking, pubmed-meshheading:15735069-Amino Acid Substitution, pubmed-meshheading:15735069-Apolipoprotein C-III, pubmed-meshheading:15735069-Apolipoproteins C, pubmed-meshheading:15735069-Case-Control Studies, pubmed-meshheading:15735069-Diabetes Mellitus, pubmed-meshheading:15735069-Dietary Fats, pubmed-meshheading:15735069-Energy Intake, pubmed-meshheading:15735069-Fatty Acids, Unsaturated, pubmed-meshheading:15735069-Female, pubmed-meshheading:15735069-Humans, pubmed-meshheading:15735069-Male, pubmed-meshheading:15735069-Middle Aged, pubmed-meshheading:15735069-PPAR alpha, pubmed-meshheading:15735069-Polymorphism, Single Nucleotide, pubmed-meshheading:15735069-Sex Characteristics, pubmed-meshheading:15735069-Smoking, pubmed-meshheading:15735069-Triglycerides
pubmed:year
2005
pubmed:articleTitle
Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study.
pubmed:affiliation
Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111-1524, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't