Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-2-28
pubmed:abstractText
Previous investigations of auditory P300 event-related potentials have provided electrophysiological evidence for attentional problems in patients with posttraumatic stress disorder (PTSD). The present study sought to evaluate the relationship between P300 deficits and underlying brain morphological abnormalities in never-treated, comorbidity-free patients with PTSD following the Tokyo subway sarin attack. Out of 47 victims recruited, 8 victims with PTSD and 13 victims without PTSD were identified. Correlational analyses were performed between auditory P300 amplitude at Pz electrode site elicited in an oddball task and anterior cingulate gray matter volume that was shown to be reduced in our previous study using voxel-based morphometry on magnetic resonance imaging. Victims with PTSD showed significantly lower amplitudes of P300 compared with victims without PTSD, and the lower P300 amplitudes at Pz were significantly associated with higher avoidance/numbing scores in the PTSD group. Furthermore, in the PTSD group only, the P300 amplitudes showed a trend toward significant positive correlation with voxel densities of the anterior cingulate cortex gray matter. These results provide the first evidence that electrophysiological deficits of controlled attention observed in patients with PTSD may be linked to underlying brain morphological abnormalities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-50
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15734342-Adult, pubmed-meshheading:15734342-Arousal, pubmed-meshheading:15734342-Attention, pubmed-meshheading:15734342-Brain Mapping, pubmed-meshheading:15734342-Cerebral Cortex, pubmed-meshheading:15734342-Chemical Warfare, pubmed-meshheading:15734342-Diagnosis, Differential, pubmed-meshheading:15734342-Electroencephalography, pubmed-meshheading:15734342-Event-Related Potentials, P300, pubmed-meshheading:15734342-Female, pubmed-meshheading:15734342-Gyrus Cinguli, pubmed-meshheading:15734342-Humans, pubmed-meshheading:15734342-Image Processing, Computer-Assisted, pubmed-meshheading:15734342-Magnetic Resonance Imaging, pubmed-meshheading:15734342-Male, pubmed-meshheading:15734342-Middle Aged, pubmed-meshheading:15734342-Personality Assessment, pubmed-meshheading:15734342-Pitch Perception, pubmed-meshheading:15734342-Railroads, pubmed-meshheading:15734342-Reaction Time, pubmed-meshheading:15734342-Sarin, pubmed-meshheading:15734342-Signal Processing, Computer-Assisted, pubmed-meshheading:15734342-Statistics as Topic, pubmed-meshheading:15734342-Stress Disorders, Post-Traumatic, pubmed-meshheading:15734342-Terrorism
pubmed:year
2005
pubmed:articleTitle
Association between lower P300 amplitude and smaller anterior cingulate cortex volume in patients with posttraumatic stress disorder: a study of victims of Tokyo subway sarin attack.
pubmed:affiliation
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Tokyo 113-8655, Japan. taraki-tky@umin.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't