Linked Life Data

15734229

Source:http://linkedlifedata.com/resource/pubmed/id/15734229

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pubmed-article:15734229pubmed:abstractTextSufficient evidence exists for the inclusion of the ventral pallidum (VP) into the category of a dopaminoceptive brain region. The effects of inhibiting dopamine D(1)- or D(2)-like receptors in the VP on (a) ethanol intake and (b) extracellular levels of dopamine, were investigated in the alcohol-preferring (P) rat. The D(1)-like antagonist, SCH-23390, and the D(2)-like antagonist, sulpiride (0.25-2 microg/0.5 microl) were bilaterally injected into the VP and ethanol (15%, v/v) intake was assessed in a 1 h limited access paradigm. The results indicate that microinjections of sulpiride significantly increased ethanol consumption (65% increase at the 2.0 microg dose). Whereas the D(1) antagonists SCH-23390 tended to decrease ethanol intake, the effect was not statistically significant. In a separate group of rats, reverse microdialysis of sulpiride and SCH-23390 (10-200 microM) were conducted in the VP of P rats. Local perfusion of only the 200 microM sulpiride dose significantly increased the extracellular levels of dopamine (maximal increase: 250% of baseline). On the other hand, local perfusion of SCH-23390 (10-200 microM) dose dependently increased the extracellular levels of dopamine 180-640% of baseline. Overall, the results of this study suggest that (a) tonic activation of D(2) postsynaptic receptors in VP imposes a limit on ethanol intake in the P rat; (b) there are few D(2) autoreceptors functioning in the VP; (c) there is tonic D(1)-like receptor mediated inhibitory feedback regulation of VP-dopamine release.lld:pubmed
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pubmed-article:15734229pubmed:authorpubmed-author:MelendezRober...lld:pubmed
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pubmed-article:15734229pubmed:pagination293-301lld:pubmed
pubmed-article:15734229pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:15734229pubmed:articleTitleDopamine receptor regulation of ethanol intake and extracellular dopamine levels in the ventral pallidum of alcohol preferring (P) rats.lld:pubmed
pubmed-article:15734229pubmed:affiliationProgram in Psychobiology of Addictions, Department of Psychology, LD 124, Purdue School of Science, Indiana University-Purdue University at Indianapolis, IUPUI, 402 N. Blackford St., Indianapolis, IN 46202-3275, USA.lld:pubmed
pubmed-article:15734229pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15734229pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:15734229pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed