Source:http://linkedlifedata.com/resource/pubmed/id/15734229
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2005-2-28
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| pubmed:abstractText |
Sufficient evidence exists for the inclusion of the ventral pallidum (VP) into the category of a dopaminoceptive brain region. The effects of inhibiting dopamine D(1)- or D(2)-like receptors in the VP on (a) ethanol intake and (b) extracellular levels of dopamine, were investigated in the alcohol-preferring (P) rat. The D(1)-like antagonist, SCH-23390, and the D(2)-like antagonist, sulpiride (0.25-2 microg/0.5 microl) were bilaterally injected into the VP and ethanol (15%, v/v) intake was assessed in a 1 h limited access paradigm. The results indicate that microinjections of sulpiride significantly increased ethanol consumption (65% increase at the 2.0 microg dose). Whereas the D(1) antagonists SCH-23390 tended to decrease ethanol intake, the effect was not statistically significant. In a separate group of rats, reverse microdialysis of sulpiride and SCH-23390 (10-200 microM) were conducted in the VP of P rats. Local perfusion of only the 200 microM sulpiride dose significantly increased the extracellular levels of dopamine (maximal increase: 250% of baseline). On the other hand, local perfusion of SCH-23390 (10-200 microM) dose dependently increased the extracellular levels of dopamine 180-640% of baseline. Overall, the results of this study suggest that (a) tonic activation of D(2) postsynaptic receptors in VP imposes a limit on ethanol intake in the P rat; (b) there are few D(2) autoreceptors functioning in the VP; (c) there is tonic D(1)-like receptor mediated inhibitory feedback regulation of VP-dopamine release.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Sulpiride
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0376-8716
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
7
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| pubmed:volume |
77
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
293-301
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15734229-Alcohol Drinking,
pubmed-meshheading:15734229-Animals,
pubmed-meshheading:15734229-Benzazepines,
pubmed-meshheading:15734229-Choice Behavior,
pubmed-meshheading:15734229-Dopamine,
pubmed-meshheading:15734229-Dopamine Antagonists,
pubmed-meshheading:15734229-Dose-Response Relationship, Drug,
pubmed-meshheading:15734229-Extracellular Fluid,
pubmed-meshheading:15734229-Feedback,
pubmed-meshheading:15734229-Female,
pubmed-meshheading:15734229-Globus Pallidus,
pubmed-meshheading:15734229-Microdialysis,
pubmed-meshheading:15734229-Microinjections,
pubmed-meshheading:15734229-Neural Inhibition,
pubmed-meshheading:15734229-Rats,
pubmed-meshheading:15734229-Rats, Inbred Strains,
pubmed-meshheading:15734229-Receptors, Dopamine D1,
pubmed-meshheading:15734229-Receptors, Dopamine D2,
pubmed-meshheading:15734229-Sulpiride
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| pubmed:year |
2005
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| pubmed:articleTitle |
Dopamine receptor regulation of ethanol intake and extracellular dopamine levels in the ventral pallidum of alcohol preferring (P) rats.
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| pubmed:affiliation |
Program in Psychobiology of Addictions, Department of Psychology, LD 124, Purdue School of Science, Indiana University-Purdue University at Indianapolis, IUPUI, 402 N. Blackford St., Indianapolis, IN 46202-3275, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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