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rdf:type |
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lifeskim:mentions |
umls-concept:C0001511,
umls-concept:C0007634,
umls-concept:C0026764,
umls-concept:C0029431,
umls-concept:C0128546,
umls-concept:C0162597,
umls-concept:C0205263,
umls-concept:C0376152,
umls-concept:C0442805,
umls-concept:C1332699,
umls-concept:C1332700,
umls-concept:C1522492
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pubmed:issue |
3
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pubmed:dateCreated |
2005-2-25
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pubmed:abstractText |
Macrophage inflammatory protein-1alpha (MIP-1alpha), an osteoclast (OCL) stimulatory factor produced by primary multiple myeloma (MM) cells, increases bone destruction and tumor burden in murine models of MM. Several chemokine receptors (CCR1, CCR5, and CCR9) mediate the effects of MIP-1alpha. In this study, we determined which of these mediates the effects of MIP-1alpha on human OCL formation and myeloma cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL3,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0301-472X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
272-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15730850-Bone Marrow Cells,
pubmed-meshheading:15730850-Cell Adhesion,
pubmed-meshheading:15730850-Cell Line, Tumor,
pubmed-meshheading:15730850-Chemokine CCL3,
pubmed-meshheading:15730850-Chemokine CCL4,
pubmed-meshheading:15730850-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15730850-Humans,
pubmed-meshheading:15730850-Macrophage Inflammatory Proteins,
pubmed-meshheading:15730850-Multiple Myeloma,
pubmed-meshheading:15730850-Osteoclasts,
pubmed-meshheading:15730850-Receptors, CCR1,
pubmed-meshheading:15730850-Receptors, CCR5,
pubmed-meshheading:15730850-Receptors, Chemokine,
pubmed-meshheading:15730850-Stromal Cells
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pubmed:year |
2005
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pubmed:articleTitle |
MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells.
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pubmed:affiliation |
Department of Medicine/Hematology-Oncology Division, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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