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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-2-24
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pubmed:abstractText |
Precise topological matching of presynaptic and postsynaptic specializations is essential for efficient synaptic transmission. Furthermore, synaptic connections are subjected to rearrangements throughout life. Here we examined the role of glutamate receptor (GluR) delta2 in the adult brain by inducible and cerebellar Purkinje cell (PC)-specific gene targeting under the pure C57BL/6 genetic background. Concomitant with the decrease of postsynaptic GluRdelta2 proteins, presynaptic active zones shrank progressively and postsynaptic density (PSD) expanded, resulting in mismatching between presynaptic and postsynaptic specializations at parallel fiber-PC synapses. Furthermore, GluRdelta2 and PSD-93 proteins were concentrated at the contacted portion of mismatched synapses, whereas AMPA receptors were distributed in both the contacted and dissociated portions. When GluRdelta2 proteins were diminished, PC spines lost their synaptic contacts. We thus identified postsynaptic GluRdelta2 as a key regulator of the presynaptic active zone and PSD organization at parallel fiber-PC synapses in the adult brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mifepristone,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor delta 2,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...,
http://linkedlifedata.com/resource/pubmed/chemical/postsynaptic density proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1529-2401
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2146-56
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15728855-Animals,
pubmed-meshheading:15728855-Cerebellum,
pubmed-meshheading:15728855-Dendrites,
pubmed-meshheading:15728855-Female,
pubmed-meshheading:15728855-Gene Targeting,
pubmed-meshheading:15728855-Guanylate Kinase,
pubmed-meshheading:15728855-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15728855-Male,
pubmed-meshheading:15728855-Membrane Proteins,
pubmed-meshheading:15728855-Mice,
pubmed-meshheading:15728855-Mice, Inbred C57BL,
pubmed-meshheading:15728855-Mice, Transgenic,
pubmed-meshheading:15728855-Microscopy, Immunoelectron,
pubmed-meshheading:15728855-Mifepristone,
pubmed-meshheading:15728855-Nerve Tissue Proteins,
pubmed-meshheading:15728855-Neuronal Plasticity,
pubmed-meshheading:15728855-Presynaptic Terminals,
pubmed-meshheading:15728855-Purkinje Cells,
pubmed-meshheading:15728855-RNA, Messenger,
pubmed-meshheading:15728855-Receptors, AMPA,
pubmed-meshheading:15728855-Receptors, Glutamate,
pubmed-meshheading:15728855-Recombinant Fusion Proteins,
pubmed-meshheading:15728855-Recombination, Genetic,
pubmed-meshheading:15728855-Synapses,
pubmed-meshheading:15728855-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Control of synaptic connection by glutamate receptor delta2 in the adult cerebellum.
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pubmed:affiliation |
Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, and Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, Tokyo 113-0033, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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