Linked Life Data

15728474

Source:http://linkedlifedata.com/resource/pubmed/id/15728474

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-2-24
pubmed:abstractText
Gammadelta T cells suppress airway hyperresponsiveness (AHR) induced in allergen-challenged mice but it is not clear whether the suppression is allergen specific. The AHR-suppressive cells express TCR-Vgamma4. To test whether the suppressive function must be induced, we adoptively transferred purified Vgamma4(+) cells into gammadelta T cell-deficient and OVA-sensitized and -challenged recipients (B6.TCR-Vgamma4(-/-)/6(-/-)) and measured the effect on AHR. Vgamma4(+) gammadelta T cells isolated from naive donors were not AHR-suppressive, but Vgamma4(+) cells from OVA-stimulated donors suppressed AHR. Suppressive Vgamma4(+) cells could be isolated from lung and spleen. Their induction in the spleen required sensitization and challenge. In the lung, their function was induced by airway challenge alone. Induction of the suppressors was associated with their activation but it did not alter their ability to accumulate in the lung. Vgamma4(+) gammadelta T cells preferentially express Vdelta4 and -5 but their AHR-suppressive function was not dependent on these Vdeltas. Donor sensitization and challenge not only with OVA but also with two unrelated allergens (ragweed and BSA) induced Vgamma4(+) cells capable of suppressing AHR in the OVA-hyperresponsive recipients, but the process of sensitization and challenge alone (adjuvant and saline only) was not sufficient to induce suppressor function, and LPS as a component of the allergen was not essential. We conclude that AHR-suppressive Vgamma4(+) gammadelta T cells require induction. They are induced by allergen stimulation, but AHR suppression by these cells does not require their restimulation with the same allergen.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
174
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2671-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:15728474-Adoptive Transfer, pubmed-meshheading:15728474-Allergens, pubmed-meshheading:15728474-Ambrosia, pubmed-meshheading:15728474-Animals, pubmed-meshheading:15728474-Antigens, Plant, pubmed-meshheading:15728474-Bronchial Hyperreactivity, pubmed-meshheading:15728474-Lymphocyte Activation, pubmed-meshheading:15728474-Mice, pubmed-meshheading:15728474-Mice, Inbred C3H, pubmed-meshheading:15728474-Mice, Inbred C57BL, pubmed-meshheading:15728474-Mice, Knockout, pubmed-meshheading:15728474-Mice, Transgenic, pubmed-meshheading:15728474-Ovalbumin, pubmed-meshheading:15728474-Plant Proteins, pubmed-meshheading:15728474-Receptors, Antigen, T-Cell, gamma-delta, pubmed-meshheading:15728474-Serum Albumin, Bovine, pubmed-meshheading:15728474-T-Lymphocyte Subsets, pubmed-meshheading:15728474-T-Lymphocytes, Regulatory
pubmed:year
2005
pubmed:articleTitle
Mismatched antigen prepares gamma delta T cells for suppression of airway hyperresponsiveness.
pubmed:affiliation
Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't