Source:http://linkedlifedata.com/resource/pubmed/id/15727088
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2005-2-24
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| pubmed:abstractText |
Circulating monocyte-platelet aggregates can release procoagulant, oxidative and mitogenic factors, thereby contributing to arterial thrombosis. The aim of our study was the estimation of heterophilic leukocyte-platelet aggregates in patients referred for coronary angiography, dependent on the degree of coronary stenosis and the disturbances of carbohydrate metabolism. Flow-cytometric analysis was performed in 50 consecutive patients with positive exercise test (age 54.2 +/- 6.4 years): 27 with normal glucose tolerance, 7 with impaired glucose tolerance and 16 with type 2 diabetes, and in 16 healthy subjects (age 44.8 +/- 14.1 years). We found that patients with coronary heart disease had increased leukocyte-platelet aggregate formation in comparison to the controls (the percentage of monocyte-platelet aggregates 47.5 +/- 23.0 vs 25.7 +/-12.8, p = 0.003, mean fluorescence intensity (MIF) 187.6 +/- 117.2 vs 79.3 +/- 42.8, p = 0.002, the percentage of granulocyte-platelet aggregates 20.7 +/- 10.4 vs 17.0 +/- 3.6, p = 0.009, MIF 64.2 +/- 41.3 vs 40.9 +/- 6.3, p = 0.008). The highest percentage of heterophilic aggregates was observed in patients with 1- and 2-vessel disease and those with "clean" vessels. In diabetic patients the percentage and MIF of granulocyte-platelet aggregates were decreased in comparison to the subjects with normal glucose tolerance (16.7 +/- 7.2 vs 22.8 +/- 9.8, p = 0.03 and 44.3 +/- 10.8 vs 74.4 +/- 48, p = 0.009, respectively). There was no increase in glycoprotein CD14 expression in any of the group studied. We found a positive correlation between the percentage of monocyte-platelet aggregates and fasting insulin level (r = 0.369, p = 0.04) and a negative correlation between MIF of monocyte-platelet aggregates and HDL level (r = -0.459, p = 0.012), between MIF CD14 and HDL level (r = -0.435, p = 0.02), and between the percentage of granulocyte-platelet aggregates and postprandial glycaemia (r = -0.4117, p = 0.03). We concluded that: 1. the patients with "clean" vessels represent a group of high atherothrombotic risk. 2. the patients with minimal coronary stenosis may benefit from anti-inflammatory and antiplatelet treatment.
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| pubmed:language |
pol
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0032-3772
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
112
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1067-73
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| pubmed:dateRevised |
2010-4-1
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| pubmed:meshHeading |
pubmed-meshheading:15727088-Adult,
pubmed-meshheading:15727088-Blood Platelets,
pubmed-meshheading:15727088-Carbohydrate Metabolism,
pubmed-meshheading:15727088-Case-Control Studies,
pubmed-meshheading:15727088-Coronary Artery Disease,
pubmed-meshheading:15727088-Coronary Disease,
pubmed-meshheading:15727088-Female,
pubmed-meshheading:15727088-Flow Cytometry,
pubmed-meshheading:15727088-Humans,
pubmed-meshheading:15727088-Male,
pubmed-meshheading:15727088-Middle Aged,
pubmed-meshheading:15727088-Monocytes,
pubmed-meshheading:15727088-Platelet Aggregation,
pubmed-meshheading:15727088-Risk Factors
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| pubmed:year |
2004
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| pubmed:articleTitle |
[Platelet-monocyte aggregate formation in patients with coronary heart disease and disorders of carbohydrate metabolism].
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| pubmed:affiliation |
Klinika Endokrynologii, Diabetologii i Chorób Wewnetrznych AM w Bia?ymstoku. telejkob@poczta.onet.pl
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| pubmed:publicationType |
Journal Article,
English Abstract
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