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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-6-1
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pubmed:abstractText |
We have established previously that human thyroid epithelial cells (TEC) from patients with autoimmune thyroiditis are able to synthesize cytokines, such as interleukin-1 (IL-1) and interleukin-6 (IL-6). This paper examines TEC in sections from autoimmune thyroiditis for the in vivo production of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) using the combined techniques of in situ hybridization and immunohistochemistry. Thyroid tissue from patients with Graves' disease, Hashimoto's disease and non-toxic goitre was examined and both mRNA and the protein of TNF-alpha were detected in TEC on frozen sections. Representative figures of only Graves' samples are illustrated in this paper. In contrast, using the same methods, IFN-gamma was detected only in the infiltrating cells and not in TEC of thyroid tissue from the patients.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-1713250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-1714602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-1930331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-1968836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-1974032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-1993363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-2045116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-2258696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-2518829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-2540776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-2784544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-3117460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-3258527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-6173769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-6334239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1572693-6392892
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
456-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1572693-Epithelium,
pubmed-meshheading:1572693-Goiter,
pubmed-meshheading:1572693-Graves Disease,
pubmed-meshheading:1572693-Humans,
pubmed-meshheading:1572693-Interferon-gamma,
pubmed-meshheading:1572693-Nucleic Acid Hybridization,
pubmed-meshheading:1572693-RNA, Messenger,
pubmed-meshheading:1572693-Thyroid Gland,
pubmed-meshheading:1572693-Thyroiditis,
pubmed-meshheading:1572693-Thyroiditis, Autoimmune,
pubmed-meshheading:1572693-Tumor Necrosis Factor-alpha
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pubmed:year |
1992
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pubmed:articleTitle |
Detection of in vivo production of tumour necrosis factor-alpha by human thyroid epithelial cells.
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pubmed:affiliation |
Kennedy Institute of Rheumatology, London, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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