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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-1
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pubmed:abstractText |
Inhibitor of apoptosis protein (IAP)-family proteins suppress apoptotic signaling in normal/neoplastic cells in various settings. To determine the apoptosis-resistant mechanism in adult acute mixed lineage leukemia (AMLL) with biphenotypic blasts responsible for resistance against chemotherapy, the expression levels of IAP-family proteins in AMLL bone marrow cells were analyzed by quantitative RT-PCR. The overall expression levels of IAPs were higher than those in control, AML, and ALL cells. A significant difference for the expression of survivin was observed between AMLL and AML (P <0.05), and differences between AMLL and ALL were significant for the expression of survivin (P <0.05), NAIP (P <0.05), and XIAP (P <0.05). These findings suggest that higher expression of various IAPs is associated with the chemotherapy-resistant nature of this specific type of leukemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0361-8609
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-80
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15726601-Adolescent,
pubmed-meshheading:15726601-Adult,
pubmed-meshheading:15726601-Aged,
pubmed-meshheading:15726601-Aged, 80 and over,
pubmed-meshheading:15726601-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15726601-Apoptosis,
pubmed-meshheading:15726601-Bone Marrow Cells,
pubmed-meshheading:15726601-Female,
pubmed-meshheading:15726601-Flow Cytometry,
pubmed-meshheading:15726601-Humans,
pubmed-meshheading:15726601-Immunohistochemistry,
pubmed-meshheading:15726601-In Situ Nick-End Labeling,
pubmed-meshheading:15726601-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:15726601-Leukemia, Biphenotypic, Acute,
pubmed-meshheading:15726601-Leukemia, Monocytic, Acute,
pubmed-meshheading:15726601-Male,
pubmed-meshheading:15726601-Microtubule-Associated Proteins,
pubmed-meshheading:15726601-Middle Aged,
pubmed-meshheading:15726601-Neoplasm Proteins,
pubmed-meshheading:15726601-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:15726601-Proteins,
pubmed-meshheading:15726601-RNA, Messenger,
pubmed-meshheading:15726601-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15726601-Tumor Markers, Biological
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pubmed:year |
2005
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pubmed:articleTitle |
Expression of IAP-family proteins in adult acute mixed lineage leukemia (AMLL).
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pubmed:affiliation |
Department of Comprehensive Pathology, Aging and Developmental Sciences, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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