Source:http://linkedlifedata.com/resource/pubmed/id/15725944
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-2-23
|
| pubmed:abstractText |
Recent studies have indicated that caveolae are enriched in a variety of signaling molecules, some of which are associated with cardiomyocyte hypertrophy. Caveolin-3, a major constituent of cardiac caveolae, has been suggested to interact with several signaling molecules. We investigated the morphologic changes of caveolae and caveolin-3 expression in hypertrophied cardiomyocytes induced by an alpha1-adrenergic agonist. Cultured rat neonatal cardiomyocytes were used for the experiments. Phenylephrine induced cellular hypertrophy associated with an increase of the number of caveolae and an up-regulation of caveolin-3. Although PMA increased the number of caveolae and the caveolin-3 expression, the extent of these up-regulations was less than that by phenylephrine. Moreover, ionomycin increased the number of caveolae and up-regulated caveolin-3 as much as phenylephrine. Phenylephrine-induced up-regulations of caveolae and caveolin-3 expression were inhibited by BAPTA, suggesting that the intracellular Ca2+ is involved in those regulations. Inhibitors of calcineurin and Ca2+calmodulin-dependent kinase II attenuated the phenylephrine-induced up-regulation of caveolin-3. In pressure-overloaded rat hearts, caveolin-3 protein levels were increased compared with sham-operated rats. In conclusion, the number of caveolae and the expression of caveolin-3 were up-regulated in rat hypertrophied cardiomyocytes, possibly via the alterations of intracellular Ca2+ and protein kinase C.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Cav3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolin 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolins,
http://linkedlifedata.com/resource/pubmed/chemical/Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol 12,13-Dibutyrate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0160-2446
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
204-10
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:15725944-Adrenergic alpha-1 Receptor Agonists,
pubmed-meshheading:15725944-Adrenergic alpha-Agonists,
pubmed-meshheading:15725944-Animals,
pubmed-meshheading:15725944-Animals, Newborn,
pubmed-meshheading:15725944-Blotting, Northern,
pubmed-meshheading:15725944-Cardiomegaly,
pubmed-meshheading:15725944-Caveolae,
pubmed-meshheading:15725944-Caveolin 3,
pubmed-meshheading:15725944-Caveolins,
pubmed-meshheading:15725944-Cell Size,
pubmed-meshheading:15725944-Cells, Cultured,
pubmed-meshheading:15725944-Immunoblotting,
pubmed-meshheading:15725944-Leucine,
pubmed-meshheading:15725944-Male,
pubmed-meshheading:15725944-Microscopy, Electron,
pubmed-meshheading:15725944-Myocytes, Cardiac,
pubmed-meshheading:15725944-Phorbol 12,13-Dibutyrate,
pubmed-meshheading:15725944-Rats,
pubmed-meshheading:15725944-Rats, Wistar,
pubmed-meshheading:15725944-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15725944-Up-Regulation
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Behavior of caveolae and caveolin-3 during the development of myocyte hypertrophy.
|
| pubmed:affiliation |
Department of Internal Medicine III and Cardiovascular Research Institute, Kurume University School of Medicine, Kurume, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|